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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3733
Preferred Name Muscarinic acetylcholine receptor M1
Synonyms Chrm-1 | Chrm1 | Muscarinic acetylcholine receptor M1
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > acetylcholine receptor

Target Components

Component Description Relationship Accession
Muscarinic acetylcholine receptor M1 SINGLE PROTEIN P12657

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2097162 Muscarinic acetylcholine receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0032279 (asymmetric synapse)
GO:0043679 (axon terminus)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0008144 (drug binding)
GO:0016907 (G-protein coupled acetylcholine receptor activity)
GO Biological Process GO:0003056 (regulation of vascular smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007197 (adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway)
GO:0007207 (phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway)
GO:0007213 (G-protein coupled acetylcholine receptor signaling pathway)
GO:0007271 (synaptic transmission, cholinergic)
GO:0007274 (neuromuscular synaptic transmission)
GO:0040012 (regulation of locomotion)
GO:0043270 (positive regulation of ion transport)
GO:0046541 (saliva secretion)
GO:0050890 (cognition)
GO:0090316 (positive regulation of intracellular protein transport)

Target Cross References - Protein

canSAR P12657
Guide to Pharmacology 13
Reactome R-MMU-390648 (Muscarinic acetylcholine receptors.)
R-MMU-416476 (G alpha (q) signalling events.)
UniProt P12657 Q52KQ0 Q8BJN3

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000995 (Musac_Ach_rcpt.)
IPR002228 (Musac_Ach_M1_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)