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Target Report Card

Target Name and Classification

Target ID CHEMBL3720
Target Type SINGLE PROTEIN
Preferred Name ATP-citrate synthase
Synonyms ACL | ACLY | ATP-citrate (pro-S-)-lyase | ATP-citrate synthase | Citrate cleavage enzyme
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
ATP-citrate synthase SINGLE PROTEIN P53396

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000131473
Ensembl ENSG00000131473
GO Cellular Component GO:0005576 (extracellular region)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0009346 (citrate lyase complex)
GO:0016020 (membrane)
GO:0035578 (azurophil granule lumen)
GO:0070062 (extracellular exosome)
GO:1904813 (ficolin-1-rich granule lumen)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003824 (catalytic activity)
GO:0003878 (ATP citrate synthase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO:0046912 (transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer)
GO:0048037 (cofactor binding)
GO Biological Process GO:0006085 (acetyl-CoA biosynthetic process)
GO:0006101 (citrate metabolic process)
GO:0006107 (oxaloacetate metabolic process)
GO:0006629 (lipid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006695 (cholesterol biosynthetic process)
GO:0008152 (metabolic process)
GO:0008610 (lipid biosynthetic process)
GO:0015936 (coenzyme A metabolic process)
GO:0031325 (positive regulation of cellular metabolic process)
GO:0043312 (neutrophil degranulation)
GO:0046949 (fatty-acyl-CoA biosynthetic process)

Target Cross References - Protein

canSAR P53396
Human Protein Atlas ENSG00000131473
IntAct P53396
Open Targets ENSG00000131473
PharmGKB PA24441
Reactome R-HSA-163765 (ChREBP activates metabolic gene expression.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-75105 (Fatty acyl-CoA biosynthesis.)
UniProt B4DIM0 B4E3P0 P53396 Q13037 Q9BRL0

Target Cross References - Domain

InterPro IPR002020 (Citrate_synthase.)
IPR003781 (CoA-bd.)
IPR005811 (CoA_ligase.)
IPR014608 (ATP-citrate_synthase.)
IPR016102 (Succinyl-CoA_synth-like.)
IPR016143 (Citrate_synth-like_sm_a-sub.)
IPR017440 (Cit_synth/succinyl-CoA_lig_AS.)
IPR017866 (Succ-CoA_synthase_bsu_CS.)
IPR032263 (Citrate-bd.)
IPR033847 (Citrt_syn/SCS-alpha_CS.)
IPR036291 (NAD(P)-bd_dom_sf.)
IPR036969 (Citrate_synthase_sf.)
Pfam PF00285 (Citrate_synt)
PF00549 (Ligase_CoA)
PF02629 (CoA_binding)
PF16114 (Citrate_bind)

Target Cross References - Structure

PDBe 3MWD 3MWE 3PFF 5TDE 5TDF 5TDM 5TDZ 5TE1 5TEQ 5TES 5TET
CREDO 3MWD 3MWE 3PFF 5TDE 5TDF 5TDM 5TDZ 5TE1 5TEQ 5TES 5TET
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