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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3712888
Target Type SINGLE PROTEIN
Preferred Name T-cell surface glycoprotein CD5
Synonyms CD5 | CD_antigen=CD5 | LEU1 | Lymphocyte antigen T1/Leu-1 | T-cell surface glycoprotein CD5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
T-cell surface glycoprotein CD5 SINGLE PROTEIN P06127

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2108785 ZOLIMOMAB ARITOX T-cell surface glycoprotein CD5 binding agent 2 PubMed
CHEMBL2108790 TELIMOMAB ARITOX T-cell surface glycoprotein CD5 binding agent 1 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000110448
Ensembl ENSG00000110448
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004888 (transmembrane signaling receptor activity)
GO:0005044 (scavenger receptor activity)
GO:0005515 (protein binding)
GO:0038023 (signaling receptor activity)
GO Biological Process GO:0006898 (receptor-mediated endocytosis)
GO:0008037 (cell recognition)
GO:0008283 (cell proliferation)
GO:0031295 (T cell costimulation)
GO:0097190 (apoptotic signaling pathway)

Target Cross References - Protein

Human Protein Atlas ENSG00000110448
IntAct P06127
Open Targets ENSG00000110448
UniProt A0N0P4 A8K9I3 P06127

Target Cross References - Domain

InterPro IPR001190 (SRCR.)
IPR003566 (Tcell_CD5.)
IPR017448 (SRCR-like_dom.)
IPR036772 (SRCR-like_dom_sf.)
Pfam PF00530 (SRCR)

Target Cross References - Structure

PDBe 2JA4 2OTT
CREDO 2JA4 2OTT
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