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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3710403
Target Type SINGLE PROTEIN
Preferred Name 14-3-3 protein beta/alpha
Synonyms 14-3-3 protein beta/alpha | 14-3-3 protein beta/alpha, N-terminally processed | KCIP-1 | Protein 1054 | Protein kinase C inhibitor protein 1 | YWHAB
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
14-3-3 protein beta/alpha SINGLE PROTEIN P31946

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166913
Ensembl ENSG00000166913

Target Cross References - Protein

Human Protein Atlas ENSG00000166913
IntAct P31946
Open Targets ENSG00000166913
Reactome R-HSA-111447 (Activation of BAD and translocation to mitochondria.)
R-HSA-1445148 (Translocation of GLUT4 to the plasma membrane.)
R-HSA-165159 (mTOR signalling.)
R-HSA-166208 (mTORC1-mediated signalling.)
R-HSA-170968 (Frs2-mediated activation.)
R-HSA-170984 (ARMS-mediated activation.)
R-HSA-2028269 (Signaling by Hippo.)
R-HSA-392517 (Rap1 signalling.)
R-HSA-450385 (Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.)
R-HSA-450513 (Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA.)
R-HSA-5625740 (RHO GTPases activate PKNs.)
R-HSA-5628897 (TP53 Regulates Metabolic Genes.)
R-HSA-5673000 (RAF activation.)
R-HSA-5674135 (MAP2K and MAPK activation.)
R-HSA-5675221 (Negative regulation of MAPK pathway.)
R-HSA-6802946 (Signaling by moderate kinase activity BRAF mutants.)
R-HSA-6802948 (Signaling by high-kinase activity BRAF mutants.)
R-HSA-6802949 (Signaling by RAS mutants.)
R-HSA-6802952 (Signaling by BRAF and RAF fusions.)
R-HSA-6802955 (Paradoxical activation of RAF signaling by kinase inactive BRAF.)
R-HSA-75035 (Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.)
UniProt A8K9K2 E1P616 P31946

Target Cross References - Domain

InterPro IPR000308 (14-3-3.)
IPR023409 (14-3-3_CS.)
IPR023410 (14-3-3_domain.)
Pfam PF00244 (14-3-3)

Target Cross References - Structure

PDBe 2BQ0 2C23 4DNK
CREDO 2BQ0 2C23 4DNK
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