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Target Report Card

Target Name and Classification

Target ID CHEMBL3710403
Preferred Name 14-3-3 protein beta/alpha
Synonyms 14-3-3 protein beta/alpha | 14-3-3 protein beta/alpha, N-terminally processed | KCIP-1 | Protein 1054 | Protein kinase C inhibitor protein 1 | YWHAB
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
14-3-3 protein beta/alpha SINGLE PROTEIN P31946

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166913
Ensembl ENSG00000166913
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0017053 (transcriptional repressor complex)
GO:0030659 (cytoplasmic vesicle membrane)
GO:0032991 (macromolecular complex)
GO:0042470 (melanosome)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003714 (transcription corepressor activity)
GO:0005515 (protein binding)
GO:0008022 (protein C-terminus binding)
GO:0019899 (enzyme binding)
GO:0019904 (protein domain specific binding)
GO:0042802 (identical protein binding)
GO:0042826 (histone deacetylase binding)
GO:0044877 (macromolecular complex binding)
GO:0045296 (cadherin binding)
GO:0050815 (phosphoserine binding)
GO:0051219 (phosphoprotein binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0006605 (protein targeting)
GO:0016032 (viral process)
GO:0035308 (negative regulation of protein dephosphorylation)
GO:0035329 (hippo signaling)
GO:0043085 (positive regulation of catalytic activity)
GO:0043488 (regulation of mRNA stability)
GO:0045744 (negative regulation of G-protein coupled receptor protein signaling pathway)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0051220 (cytoplasmic sequestering of protein)
GO:0051291 (protein heterooligomerization)
GO:0061024 (membrane organization)
GO:1900740 (positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)

Target Cross References - Protein

Human Protein Atlas ENSG00000166913
IntAct P31946
Open Targets ENSG00000166913
Reactome R-HSA-111447 (Activation of BAD and translocation to mitochondria.)
R-HSA-1445148 (Translocation of GLUT4 to the plasma membrane.)
R-HSA-165159 (mTOR signalling.)
R-HSA-166208 (mTORC1-mediated signalling.)
R-HSA-170968 (Frs2-mediated activation.)
R-HSA-170984 (ARMS-mediated activation.)
R-HSA-2028269 (Signaling by Hippo.)
R-HSA-392517 (Rap1 signalling.)
R-HSA-450385 (Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.)
R-HSA-450513 (Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA.)
R-HSA-5625740 (RHO GTPases activate PKNs.)
R-HSA-5628897 (TP53 Regulates Metabolic Genes.)
R-HSA-5673000 (RAF activation.)
R-HSA-5674135 (MAP2K and MAPK activation.)
R-HSA-5675221 (Negative regulation of MAPK pathway.)
R-HSA-6802946 (Signaling by moderate kinase activity BRAF mutants.)
R-HSA-6802948 (Signaling by high-kinase activity BRAF mutants.)
R-HSA-6802949 (Signaling by RAS mutants.)
R-HSA-6802952 (Signaling by BRAF and RAF fusions.)
R-HSA-6802955 (Paradoxical activation of RAF signaling by kinase inactive BRAF.)
R-HSA-75035 (Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.)
UniProt A8K9K2 E1P616 P31946

Target Cross References - Domain

InterPro IPR000308 (14-3-3.)
IPR023409 (14-3-3_CS.)
IPR023410 (14-3-3_domain.)
IPR036815 (14-3-3_dom_sf.)
Pfam PF00244 (14-3-3)

Target Cross References - Structure

PDBe 2BQ0 2C23 4DNK 5N10
CREDO 2BQ0 2C23 4DNK 5N10