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Target Report Card

Target Name and Classification

Target ID CHEMBL3707
Preferred Name Beta-2 adrenergic receptor
Synonyms Adrb2 | Adrb2r | Beta-2 adrenergic receptor | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Beta-2 adrenergic receptor SINGLE PROTEIN P18762

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111395 Beta-adrenergic receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0032809 (neuronal cell body membrane)
GO:0042383 (sarcolemma)
GO:0043197 (dendritic spine)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0043235 (receptor complex)
GO Molecular Function GO:0001965 (G-protein alpha-subunit binding)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004941 (beta2-adrenergic receptor activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0008179 (adenylate cyclase binding)
GO:0015459 (potassium channel regulator activity)
GO:0019899 (enzyme binding)
GO:0031713 (B2 bradykinin receptor binding)
GO:0032403 (protein complex binding)
GO:0035240 (dopamine binding)
GO:0035255 (ionotropic glutamate receptor binding)
GO:0042803 (protein homodimerization activity)
GO:0051379 (epinephrine binding)
GO:0051380 (norepinephrine binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0001889 (liver development)
GO:0001993 (regulation of systemic arterial blood pressure by norepinephrine-epinephrine)
GO:0002024 (diet induced thermogenesis)
GO:0002025 (vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure)
GO:0002028 (regulation of sodium ion transport)
GO:0002032 (desensitization of G-protein coupled receptor protein signaling pathway by arrestin)
GO:0002086 (diaphragm contraction)
GO:0003059 (positive regulation of the force of heart contraction by epinephrine)
GO:0006898 (receptor-mediated endocytosis)
GO:0006940 (regulation of smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007267 (cell-cell signaling)
GO:0007565 (female pregnancy)
GO:0007568 (aging)
GO:0008284 (positive regulation of cell proliferation)
GO:0008306 (associative learning)
GO:0009409 (response to cold)
GO:0010765 (positive regulation of sodium ion transport)
GO:0016525 (negative regulation of angiogenesis)
GO:0030279 (negative regulation of ossification)
GO:0030501 (positive regulation of bone mineralization)
GO:0031398 (positive regulation of protein ubiquitination)
GO:0031649 (heat generation)
GO:0032570 (response to progesterone)
GO:0032781 (positive regulation of ATPase activity)
GO:0033574 (response to testosterone)
GO:0035249 (synaptic transmission, glutamatergic)
GO:0035811 (negative regulation of urine volume)
GO:0040015 (negative regulation of multicellular organism growth)
GO:0042060 (wound healing)
GO:0042312 (regulation of vasodilation)
GO:0043065 (positive regulation of apoptotic process)
GO:0043268 (positive regulation of potassium ion transport)
GO:0043410 (positive regulation of MAPK cascade)
GO:0043627 (response to estrogen)
GO:0044849 (estrous cycle)
GO:0045453 (bone resorption)
GO:0045823 (positive regulation of heart contraction)
GO:0045909 (positive regulation of vasodilation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0045986 (negative regulation of smooth muscle contraction)
GO:0048633 (positive regulation of skeletal muscle tissue growth)
GO:0050728 (negative regulation of inflammatory response)
GO:0050873 (brown fat cell differentiation)
GO:0051924 (regulation of calcium ion transport)
GO:0051930 (regulation of sensory perception of pain)
GO:0060079 (excitatory postsynaptic potential)
GO:0071456 (cellular response to hypoxia)
GO:0071548 (response to dexamethasone)
GO:0071867 (response to monoamine)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
GO:0090331 (negative regulation of platelet aggregation)
GO:0097421 (liver regeneration)
GO:0098779 (mitophagy in response to mitochondrial depolarization)
GO:1901098 (positive regulation of autophagosome maturation)
GO:1904504 (positive regulation of lipophagy)
GO:1904925 (positive regulation of mitophagy in response to mitochondrial depolarization)

Target Cross References - Protein

IntAct P18762
Reactome R-MMU-390696 (Adrenoceptors.)
R-MMU-418555 (G alpha (s) signalling events.)
R-MMU-5689880 (Ub-specific processing proteases.)
R-MMU-8856825 (Cargo recognition for clathrin-mediated endocytosis.)
R-MMU-8856828 (Clathrin-mediated endocytosis.)
UniProt P18762 Q8BH38

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000332 (ADRB2_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)