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Target Report Card

Target Name and Classification

Target ID CHEMBL3706
Preferred Name ADAM17
Synonyms ADAM 17 | ADAM17 | CD_antigen=CD156b | CSVP | Disintegrin and metalloproteinase domain-containing protein 17 | Snake venom-like protease | TACE | TNF-alpha convertase | TNF-alpha-converting enzyme
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m12b subfamily

Target Components

Component Description Relationship Accession
Disintegrin and metalloproteinase domain-containing protein 17 SINGLE PROTEIN P78536

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000151694
Ensembl ENSG00000151694
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005911 (cell-cell junction)
GO:0005925 (focal adhesion)
GO:0009986 (cell surface)
GO:0015629 (actin cytoskeleton)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0032587 (ruffle membrane)
GO:0045121 (membrane raft)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0005112 (Notch binding)
GO:0005138 (interleukin-6 receptor binding)
GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0016787 (hydrolase activity)
GO:0017124 (SH3 domain binding)
GO:0030165 (PDZ domain binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0002446 (neutrophil mediated immunity)
GO:0002467 (germinal center formation)
GO:0002690 (positive regulation of leukocyte chemotaxis)
GO:0006508 (proteolysis)
GO:0006509 (membrane protein ectodomain proteolysis)
GO:0007155 (cell adhesion)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007219 (Notch signaling pathway)
GO:0007220 (Notch receptor processing)
GO:0008284 (positive regulation of cell proliferation)
GO:0010820 (positive regulation of T cell chemotaxis)
GO:0030183 (B cell differentiation)
GO:0030307 (positive regulation of cell growth)
GO:0030335 (positive regulation of cell migration)
GO:0030511 (positive regulation of transforming growth factor beta receptor signaling pathway)
GO:0030512 (negative regulation of transforming growth factor beta receptor signaling pathway)
GO:0031293 (membrane protein intracellular domain proteolysis)
GO:0031659 (positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle)
GO:0032496 (response to lipopolysaccharide)
GO:0032722 (positive regulation of chemokine production)
GO:0033025 (regulation of mast cell apoptotic process)
GO:0033077 (T cell differentiation in thymus)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0033627 (cell adhesion mediated by integrin)
GO:0035313 (wound healing, spreading of epidermal cells)
GO:0035625 (epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway)
GO:0042493 (response to drug)
GO:0043536 (positive regulation of blood vessel endothelial cell migration)
GO:0045741 (positive regulation of epidermal growth factor-activated receptor activity)
GO:0048536 (spleen development)
GO:0048870 (cell motility)
GO:0050830 (defense response to Gram-positive bacterium)
GO:0051088 (PMA-inducible membrane protein ectodomain proteolysis)
GO:0051272 (positive regulation of cellular component movement)
GO:0071403 (cellular response to high density lipoprotein particle stimulus)
GO:1903265 (positive regulation of tumor necrosis factor-mediated signaling pathway)
GO:1905564 (positive regulation of vascular endothelial cell proliferation)
Wikipedia ADAM17

Target Cross References - Protein

canSAR P78536
CGD Inflammatory skin and bowel disease, neonatal
Human Protein Atlas ENSG00000151694
IntAct P78536
Guide to Pharmacology 1662
Open Targets ENSG00000151694
PharmGKB PA24512
Reactome R-HSA-1251985 (Nuclear signaling by ERBB4.)
R-HSA-1442490 (Collagen degradation.)
R-HSA-177929 (Signaling by EGFR.)
R-HSA-193692 (Regulated proteolysis of p75NTR.)
R-HSA-2122948 (Activated NOTCH1 Transmits Signal to the Nucleus.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2660826 (Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.)
R-HSA-2691232 (Constitutive Signaling by NOTCH1 HD Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-5362798 (Release of Hh-Np from the secreting cell.)
R-HSA-75893 (TNF signaling.)
R-HSA-982772 (Growth hormone receptor signaling.)
UniProt O60226 P78536

Target Cross References - Domain

InterPro IPR001590 (Peptidase_M12B.)
IPR001762 (Disintegrin_dom.)
IPR002870 (Peptidase_M12B_N.)
IPR024079 (MetalloPept_cat_dom_sf.)
IPR032029 (ADAM17_MPD.)
IPR034025 (ADAM10_ADAM17.)
IPR036436 (Disintegrin_dom_sf.)
Pfam PF00200 (Disintegrin)
PF01562 (Pep_M12B_propep)
PF16698 (ADAM17_MPD)

Target Cross References - Structure

PDBe 1BKC 1ZXC 2A8H 2DDF 2FV5 2FV9 2I47 2OI0 3B92 3CKI 3E8R 3EDZ 3EWJ 3G42 3KMC 3KME 3L0T 3L0V 3LE9 3LEA 3LGP 3O64
CREDO 1BKC 1ZXC 2A8H 2DDF 2FV5 2FV9 2I47 2OI0 3B92 3CKI 3E8R 3EDZ 3EWJ 3G42 3KMC 3KME 3L0T 3L0V 3LE9 3LEA 3LGP 3O64