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Target Report Card

Target Name and Classification

Target ID CHEMBL3687
Preferred Name Arachidonate 12-lipoxygenase
Synonyms 12LO | 12S-LOX | 12S-lipoxygenase | ALOX12 | Arachidonate 12-lipoxygenase, 12S-type | LOG12 | Lipoxin synthase 12-LO | Platelet-type lipoxygenase 12
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Arachidonate 12-lipoxygenase, 12S-type SINGLE PROTEIN P18054

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL340978 BENOXAPROFEN Arachidonate 12-lipoxygenase inhibitor 4 PubMed PubMed PubMed PubMed PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000108839
Ensembl ENSG00000108839
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0042383 (sarcolemma)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004052 (arachidonate 12-lipoxygenase activity)
GO:0005506 (iron ion binding)
GO:0005515 (protein binding)
GO:0016165 (linoleate 13S-lipoxygenase activity)
GO:0016491 (oxidoreductase activity)
GO:0016702 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO:0047977 (hepoxilin-epoxide hydrolase activity)
GO:0051120 (hepoxilin A3 synthase activity)
GO:0051213 (dioxygenase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0010656 (negative regulation of muscle cell apoptotic process)
GO:0019369 (arachidonic acid metabolic process)
GO:0019372 (lipoxygenase pathway)
GO:0019395 (fatty acid oxidation)
GO:0042554 (superoxide anion generation)
GO:0043651 (linoleic acid metabolic process)
GO:0051121 (hepoxilin metabolic process)
GO:0051122 (hepoxilin biosynthetic process)
GO:0055114 (oxidation-reduction process)
GO:0061436 (establishment of skin barrier)
GO:0090331 (negative regulation of platelet aggregation)
GO:1901751 (leukotriene A4 metabolic process)
GO:2001301 (lipoxin biosynthetic process)
GO:2001303 (lipoxin A4 biosynthetic process)
GO:2001306 (lipoxin B4 biosynthetic process)
Wikipedia ALOX12

Target Cross References - Protein

canSAR P18054
Human Protein Atlas ENSG00000108839
IntAct P18054
Guide to Pharmacology 1387
Open Targets ENSG00000108839
PharmGKB PA45
Reactome R-HSA-2142696 (Synthesis of Hepoxilins (HX) and Trioxilins (TrX).)
R-HSA-2142700 (Synthesis of Lipoxins (LX).)
R-HSA-2142712 (Synthesis of 12-eicosatetraenoic acid derivatives.)
UniProt O95569 P18054 Q6ISF8 Q9UQM4

Target Cross References - Domain

InterPro IPR000907 (LipOase.)
IPR001024 (PLAT/LH2_dom.)
IPR001885 (LipOase_mml.)
IPR013819 (LipOase_C.)
IPR020833 (LipOase_Fe_BS.)
IPR020834 (LipOase_CS.)
IPR036226 (LipOase_C_sf.)
IPR036392 (PLAT/LH2_dom_sf.)
Pfam PF00305 (Lipoxygenase)
PF01477 (PLAT)

Target Cross References - Structure