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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3684
Preferred Name Glutamate receptor ionotropic kainate 3
Synonyms EAA5 | Excitatory amino acid receptor 5 | GLUR7 | GRIK3 | GluK3 | GluR-7 | GluR7 | Glutamate receptor 7 | Glutamate receptor ionotropic, kainate 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > kainate receptor

Target Components

Component Description Relationship Accession
Glutamate receptor ionotropic, kainate 3 SINGLE PROTEIN Q13003

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2109241 Glutamate receptor ionotropic kainate PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000163873
Ensembl ENSG00000163873
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0032839 (dendrite cytoplasm)
GO:0043195 (terminal bouton)
GO:0043204 (perikaryon)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0001640 (adenylate cyclase inhibiting G-protein coupled glutamate receptor activity)
GO:0001664 (G-protein coupled receptor binding)
GO:0004970 (ionotropic glutamate receptor activity)
GO:0005216 (ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0008066 (glutamate receptor activity)
GO:0015276 (ligand-gated ion channel activity)
GO:0015277 (kainate selective glutamate receptor activity)
GO:0038023 (signaling receptor activity)
GO Biological Process GO:0006811 (ion transport)
GO:0007196 (adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway)
GO:0007215 (glutamate receptor signaling pathway)
GO:0007216 (G-protein coupled glutamate receptor signaling pathway)
GO:0034220 (ion transmembrane transport)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0042391 (regulation of membrane potential)
GO:0051967 (negative regulation of synaptic transmission, glutamatergic)
GO:0060079 (excitatory postsynaptic potential)
Wikipedia GRIK3

Target Cross References - Protein

canSAR Q13003
Human Protein Atlas ENSG00000163873
Guide to Pharmacology 452
Open Targets ENSG00000163873
PharmGKB PA28975
Pharos Q13003 (Tclin)
Reactome R-HSA-451308 (Activation of Ca-permeable Kainate Receptor.)
R-HSA-500657 (Presynaptic function of Kainate receptors.)
UniProt A9Z1Z8 B1AMS6 Q13003 Q13004 Q16136

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10613 (Lig_chan-Glu_bd)