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Target Report Card

Target Name and Classification

Target ID CHEMBL3683
Target Type SINGLE PROTEIN
Preferred Name Glutamate receptor ionotropic kainate 2
Synonyms EAA4 | Excitatory amino acid receptor 4 | GLUR6 | GRIK2 | GluK2 | GluR-6 | GluR6 | Glutamate receptor 6 | Glutamate receptor ionotropic, kainate 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > kainate receptor

Target Components

Component Description Relationship Accession
Glutamate receptor ionotropic, kainate 2 SINGLE PROTEIN Q13002

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038480 Ionotropic glutamate receptor kainate 2/5 PROTEIN COMPLEX
CHEMBL2109241 Glutamate receptor ionotropic kainate PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164418
Ensembl ENSG00000164418
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0008328 (ionotropic glutamate receptor complex)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0032839 (dendrite cytoplasm)
GO:0032983 (kainate selective glutamate receptor complex)
GO:0042734 (presynaptic membrane)
GO:0043025 (neuronal cell body)
GO:0043195 (terminal bouton)
GO:0043204 (perikaryon)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004970 (ionotropic glutamate receptor activity)
GO:0005216 (ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0008066 (glutamate receptor activity)
GO:0015276 (ligand-gated ion channel activity)
GO:0015277 (kainate selective glutamate receptor activity)
GO:0030165 (PDZ domain binding)
GO:0031624 (ubiquitin conjugating enzyme binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0038023 (signaling receptor activity)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0001662 (behavioral fear response)
GO:0006811 (ion transport)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006886 (intracellular protein transport)
GO:0007215 (glutamate receptor signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0019228 (neuronal action potential)
GO:0034220 (ion transmembrane transport)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0035249 (synaptic transmission, glutamatergic)
GO:0042391 (regulation of membrane potential)
GO:0043113 (receptor clustering)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0043525 (positive regulation of neuron apoptotic process)
GO:0046328 (regulation of JNK cascade)
GO:0048169 (regulation of long-term neuronal synaptic plasticity)
GO:0048172 (regulation of short-term neuronal synaptic plasticity)
GO:0050804 (modulation of synaptic transmission)
GO:0050806 (positive regulation of synaptic transmission)
GO:0051402 (neuron apoptotic process)
GO:0051967 (negative regulation of synaptic transmission, glutamatergic)
GO:0060079 (excitatory postsynaptic potential)
GO:0060080 (inhibitory postsynaptic potential)
Wikipedia GRIK2

Target Cross References - Protein

canSAR Q13002
CGD Mental retardation, autosomal recessive 6
Human Protein Atlas ENSG00000164418
IntAct Q13002
Guide to Pharmacology 451
Open Targets ENSG00000164418
PharmGKB PA164741600
Pharos Q13002 (Tclin)
Reactome R-HSA-451307 (Activation of Na-permeable kainate receptors.)
R-HSA-451308 (Activation of Ca-permeable Kainate Receptor.)
UniProt A6NMY9 B5MCV0 D7RWZ3 D7RWZ4 D7RWZ5 D7RWZ6 D7RWZ7 Q13002 Q8WWS1 Q96KS6 Q96KS7 Q96KS8

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10613 (Lig_chan-Glu_bd)

Target Cross References - Structure

PDBe 3QXM 5CMM
CREDO 3QXM 5CMM
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