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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3670
Preferred Name 3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type II
Synonyms 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II | 3-beta-HSD II | 3-beta-HSD adrenal and gonadal type | 3-beta-hydroxy-5-ene steroid dehydrogenase | 3-beta-hydroxy-Delta(5)-steroid dehydrogenase | Delta-5-3-ketosteroid isomerase | HSD3B2 | HSDB3B | Progesterone reductase | Steroid Delta-isomerase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 SINGLE PROTEIN P26439

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1200907 TRILOSTANE 3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type II inhibitor 4 ISBN

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000203859
Ensembl ENSG00000203859
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0005758 (mitochondrial intermembrane space)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030868 (smooth endoplasmic reticulum membrane)
GO:0031966 (mitochondrial membrane)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0003854 (3-beta-hydroxy-delta5-steroid dehydrogenase activity)
GO:0004769 (steroid delta-isomerase activity)
GO:0016491 (oxidoreductase activity)
GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
GO:0016853 (isomerase activity)
GO:0102294 (cholesterol dehydrogenase activity)
GO Biological Process GO:0006694 (steroid biosynthetic process)
GO:0006702 (androgen biosynthetic process)
GO:0006704 (glucocorticoid biosynthetic process)
GO:0006705 (mineralocorticoid biosynthetic process)
GO:0008152 (metabolic process)
GO:0055114 (oxidation-reduction process)
Wikipedia HSD3B2

Target Cross References - Protein

canSAR P26439
CGD 3-beta-hydroxysteroid dehydrogenase, type II, deficiency
Human Protein Atlas ENSG00000203859
Open Targets ENSG00000203859
PharmGKB PA29487
Reactome R-HSA-193048 (Androgen biosynthesis.)
R-HSA-193993 (Mineralocorticoid biosynthesis.)
R-HSA-194002 (Glucocorticoid biosynthesis.)
UniProt A2RRA5 P26439 Q16010 Q53GD4 Q6AI10 Q6LDB9 Q99890 Q9UD08

Target Cross References - Domain

InterPro IPR002225 (3Beta_OHSteriod_DH/Estase.)
IPR036291 (NAD(P)-bd_dom_sf.)
Pfam PF01073 (3Beta_HSD)