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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3666
Target Type SINGLE PROTEIN
Preferred Name Serotonin 3a (5-HT3a) receptor
Synonyms 5-HT-3 | 5-HT3-A | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 | 5-hydroxytryptamine receptor 3A | 5HT3R | HTR3 | HTR3A | Serotonin receptor 3A | Serotonin-gated ion channel receptor
Organism Cavia porcellus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > 5ht3 receptor

Target Components

Component Description Relationship Accession
5-hydroxytryptamine receptor 3A SINGLE PROTEIN O70212

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030285 (integral component of synaptic vesicle membrane)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004890 (GABA-A receptor activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0015276 (ligand-gated ion channel activity)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006812 (cation transport)
GO:0007165 (signal transduction)
GO:0034220 (ion transmembrane transport)

Target Cross References - Protein

canSAR O70212
UniProt O70212 O70213

Target Cross References - Domain

InterPro IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR008132 (5HT3_rcpt.)
IPR008133 (5HT3_rcpt_A.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR027361 (Acetylcholine_rcpt_TM.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)
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