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Target Report Card

Target Name and Classification

Target ID CHEMBL3655
Preferred Name Tyrosine-protein kinase SRC
Synonyms Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src | SRC | p60-Src | pp60c-src
Organism Gallus gallus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase src family

Target Components

Component Description Relationship Accession
Proto-oncogene tyrosine-protein kinase Src SINGLE PROTEIN P00523

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0005768 (endosome)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0010008 (endosome membrane)
GO:0016020 (membrane)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0032991 (macromolecular complex)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019903 (protein phosphatase binding)
GO:0020037 (heme binding)
GO:0051427 (hormone receptor binding)
GO:0070851 (growth factor receptor binding)
GO:0071253 (connexin binding)
GO Biological Process GO:0002376 (immune system process)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007155 (cell adhesion)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007417 (central nervous system development)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0030520 (intracellular estrogen receptor signaling pathway)
GO:0036035 (osteoclast development)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042127 (regulation of cell proliferation)
GO:0045087 (innate immune response)
GO:0045453 (bone resorption)
GO:0048008 (platelet-derived growth factor receptor signaling pathway)
GO:0050847 (progesterone receptor signaling pathway)
GO:0051726 (regulation of cell cycle)
GO:0071801 (regulation of podosome assembly)
GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway)
GO:2001243 (negative regulation of intrinsic apoptotic signaling pathway)

Target Cross References - Protein

canSAR P00523
IntAct P00523
Reactome R-GGA-1227986 (Signaling by ERBB2.)
R-GGA-1257604 (PIP3 activates AKT signaling.)
R-GGA-1295596 (Spry regulation of FGF signaling.)
R-GGA-1433557 (Signaling by SCF-KIT.)
R-GGA-1433559 (Regulation of KIT signaling.)
R-GGA-177929 (Signaling by EGFR.)
R-GGA-180292 (GAB1 signalosome.)
R-GGA-186763 (Downstream signal transduction.)
R-GGA-191647 (c-src mediated regulation of Cx43 function and closure of gap junctions.)
R-GGA-354192 (Integrin alphaIIb beta3 signaling.)
R-GGA-354194 (GRB2:SOS provides linkage to MAPK signaling for Integrins.)
R-GGA-372708 (p130Cas linkage to MAPK signaling for integrins.)
R-GGA-389356 (CD28 co-stimulation.)
R-GGA-389513 (CTLA4 inhibitory signaling.)
R-GGA-3928662 (EPHB-mediated forward signaling.)
R-GGA-3928663 (EPHA-mediated growth cone collapse.)
R-GGA-3928664 (Ephrin signaling.)
R-GGA-3928665 (EPH-ephrin mediated repulsion of cells.)
R-GGA-418592 (ADP signalling through P2Y purinoceptor 1.)
R-GGA-418885 (DCC mediated attractive signaling.)
R-GGA-430116 (GP1b-IX-V activation signalling.)
R-GGA-4420097 (VEGFA-VEGFR2 Pathway.)
R-GGA-456926 (Thrombin signalling through proteinase activated receptors (PARs).)
R-GGA-5218921 (VEGFR2 mediated cell proliferation.)
R-GGA-5663220 (RHO GTPases Activate Formins.)
R-GGA-5674135 (MAP2K and MAPK activation.)
R-GGA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-GGA-8853659 (RET signaling.)
R-GGA-8874081 (MET activates PTK2 signaling.)
R-GGA-8934593 (Regulation of RUNX1 Expression and Activity.)
R-GGA-8934903 (Receptor Mediated Mitophagy.)
R-GGA-8941858 (Regulation of RUNX3 expression and activity.)
UniProt P00523 Q90992 Q90993 Q91343 Q91345 Q92013 Q98915

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR036028 (SH3-like_dom_sf.)
IPR036860 (SH2_dom_sf.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1F1W 1F2F 1P13 2HWO 2HWP 2OIQ 2PTK 2QI8 2QLQ 2QQ7 3D7T 3D7U 3DQW 3DQX 3EL7 3EL8 3EN4 3EN5 3EN6 3EN7 3F3T 3F3U 3F3V 3F3W More...
CREDO 1F1W 1F2F 1P13 2HWO 2HWP 2OIQ 2PTK 2QI8 2QLQ 2QQ7 3D7T 3D7U 3DQW 3DQX 3EL7 3EL8 3EN4 3EN5 3EN6 3EN7 3F3T 3F3U 3F3V 3F3W More...