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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3649
Target Type SINGLE PROTEIN
Preferred Name Xanthine dehydrogenase
Synonyms XDH | XOR | Xanthine dehydrogenase | Xanthine dehydrogenase/oxidase | Xanthine oxidase | Xanthine oxidoreductase
Organism Bos taurus
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Xanthine dehydrogenase/oxidase SINGLE PROTEIN P80457

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0002197 (xanthine dehydrogenase complex)
GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005777 (peroxisome)
GO:0005829 (cytosol)
GO Molecular Function GO:0004854 (xanthine dehydrogenase activity)
GO:0004855 (xanthine oxidase activity)
GO:0005506 (iron ion binding)
GO:0009055 (electron carrier activity)
GO:0016491 (oxidoreductase activity)
GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors)
GO:0016903 (oxidoreductase activity, acting on the aldehyde or oxo group of donors)
GO:0030151 (molybdenum ion binding)
GO:0042803 (protein homodimerization activity)
GO:0043546 (molybdopterin cofactor binding)
GO:0046872 (metal ion binding)
GO:0050660 (flavin adenine dinucleotide binding)
GO:0051536 (iron-sulfur cluster binding)
GO:0051537 (2 iron, 2 sulfur cluster binding)
GO:0071949 (FAD binding)
GO Biological Process GO:0009115 (xanthine catabolic process)
GO:0022900 (electron transport chain)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

canSAR P80457
UniProt P80457 Q95325

Target Cross References - Domain

InterPro IPR000674 (Ald_Oxase/Xan_DH_a/b.)
IPR001041 (2Fe-2S_ferredoxin-type.)
IPR002346 (Mopterin_DH_FAD-bd.)
IPR002888 (2Fe-2S-bd.)
IPR005107 (CO_DH_flav_C.)
IPR006058 (2Fe2S_fd_BS.)
IPR008274 (AldOxase/xan_DH_Mopterin-bd.)
IPR014307 (Xanthine_DH_ssu.)
IPR016166 (FAD-bd_2.)
IPR016208 (Ald_Oxase/xanthine_DH.)
IPR022407 (OxRdtase_Mopterin_BS.)
IPR036010 (2Fe-2S_ferredoxin-like_sf.)
IPR036318 (FAD-bd_2-like_sf.)
IPR036683 (CO_DH_flav_C_dom_sf.)
IPR036856 (Ald_Oxase/Xan_DH_a/b_sf.)
IPR036884 (2Fe-2S-bd_dom_sf.)
IPR037165 (AldOxase/xan_DH_Mopterin-bd_sf.)
Pfam PF00111 (Fer2)
PF00941 (FAD_binding_5)
PF01315 (Ald_Xan_dh_C)
PF01799 (Fer2_2)
PF02738 (Ald_Xan_dh_C2)
PF03450 (CO_deh_flav_C)

Target Cross References - Structure

PDBe 1FIQ 1FO4 1N5X 1V97 1VDV 3AM9 3AMZ 3AX7 3AX9 3B9J 3BDJ 3ETR 3EUB 3NRZ 3NS1 3NVV 3NVW 3NVY 3NVZ 3SR6 3UNA 3UNC 3UNI
CREDO 1FIQ 1FO4 1N5X 1V97 1VDV 3AM9 3AMZ 3AX7 3AX9 3B9J 3BDJ 3ETR 3EUB 3NRZ 3NS1 3NVV 3NVW 3NVY 3NVZ 3SR6 3UNA 3UNC 3UNI
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