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Target Report Card

Target Name and Classification

Target ID CHEMBL3629
Preferred Name Casein kinase II alpha
Synonyms CK II alpha | CK2A1 | CSNK2A1 | Casein kinase II subunit alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase ck2 family

Target Components

Component Description Relationship Accession
Casein kinase II subunit alpha SINGLE PROTEIN P68400

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3832943 Casein kinase 2 PROTEIN FAMILY
CHEMBL3038477 Casein kinase II alpha/beta PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1230165 SILMITASERTIB Casein kinase II alpha inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101266
Ensembl ENSG00000101266
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005956 (protein kinase CK2 complex)
GO:0016580 (Sin3 complex)
GO:0016581 (NuRD complex)
GO:0031519 (PcG protein complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042802 (identical protein binding)
GO:0047485 (protein N-terminus binding)
GO:0051879 (Hsp90 protein binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007049 (cell cycle)
GO:0007165 (signal transduction)
GO:0008284 (positive regulation of cell proliferation)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0030177 (positive regulation of Wnt signaling pathway)
GO:0030307 (positive regulation of cell growth)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0045732 (positive regulation of protein catabolic process)
GO:0048511 (rhythmic process)
GO:0061077 (chaperone-mediated protein folding)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1905818 (regulation of chromosome separation)
GO:2000059 (negative regulation of ubiquitin-dependent protein catabolic process)
GO:2001234 (negative regulation of apoptotic signaling pathway)
Wikipedia Casein_kinase_2,_alpha_1

Target Cross References - Protein

canSAR P68400
Human Protein Atlas ENSG00000101266
IntAct P68400
Guide to Pharmacology 1549
Open Targets ENSG00000101266
PharmGKB PA26957
Pharos P68400 (Tchem)
Reactome R-HSA-1483191 (Synthesis of PC.)
R-HSA-201688 (WNT mediated activation of DVL.)
R-HSA-2514853 (Condensation of Prometaphase Chromosomes.)
R-HSA-445144 (Signal transduction by L1.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
R-HSA-6814122 (Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.)
R-HSA-8934903 (Receptor Mediated Mitophagy.)
R-HSA-8939243 (RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.)
R-HSA-8948751 (Regulation of PTEN stability and activity.)
UniProt B4DYS6 D3DVV8 P19138 P20426 P68400 Q14013 Q5U065

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1JWH 1NA7 1PJK 2PVR 2ZJW 3AMY 3AT2 3AT3 3AT4 3AXW 3BQC 3C13 3FWQ 3H30 3JUH 3MB6 3MB7 3NGA 3NSZ 3OWJ 3OWK 3OWL 3PE1 3PE2 More...
CREDO 1JWH 1NA7 1PJK 2PVR 2ZJW 3AMY 3AT2 3AT3 3AT4 3AXW 3BQC 3C13 3FWQ 3H30 3JUH 3MB6 3MB7 3NGA 3NSZ 3OWJ 3OWK 3OWL 3PE1 3PE2 More...