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Target Report Card

Target Name and Classification

Target ID CHEMBL3614
Preferred Name Kappa opioid receptor
Synonyms K-OR-1 | KOR-1 | Kappa-type opioid receptor | Oprk1 | Ror-d
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > opioid receptor

Target Components

Component Description Relationship Accession
Kappa-type opioid receptor SINGLE PROTEIN P34975

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094129 Opioid receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030425 (dendrite)
GO:0043025 (neuronal cell body)
GO:0043204 (perikaryon)
GO:0043679 (axon terminus)
GO:0045202 (synapse)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004985 (opioid receptor activity)
GO:0005515 (protein binding)
GO:0038048 (dynorphin receptor activity)
GO:0042923 (neuropeptide binding)
GO Biological Process GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007218 (neuropeptide signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007610 (behavior)
GO:0007626 (locomotory behavior)
GO:0009314 (response to radiation)
GO:0019233 (sensory perception of pain)
GO:0031635 (adenylate cyclase-inhibiting opioid receptor signaling pathway)
GO:0032868 (response to insulin)
GO:0033603 (positive regulation of dopamine secretion)
GO:0033685 (negative regulation of luteinizing hormone secretion)
GO:0038003 (opioid receptor signaling pathway)
GO:0040017 (positive regulation of locomotion)
GO:0042220 (response to cocaine)
GO:0042711 (maternal behavior)
GO:0042755 (eating behavior)
GO:0043278 (response to morphine)
GO:0043627 (response to estrogen)
GO:0044849 (estrous cycle)
GO:0045471 (response to ethanol)
GO:0046877 (regulation of saliva secretion)
GO:0048148 (behavioral response to cocaine)
GO:0050951 (sensory perception of temperature stimulus)
GO:0051607 (defense response to virus)
GO:0051930 (regulation of sensory perception of pain)
GO:0071222 (cellular response to lipopolysaccharide)
GO:1900745 (positive regulation of p38MAPK cascade)
GO:1901381 (positive regulation of potassium ion transmembrane transport)
GO:1903937 (response to acrylamide)
GO:1904000 (positive regulation of eating behavior)
GO:1990708 (conditioned place preference)

Target Cross References - Protein

canSAR P34975
IntAct P34975
Guide to Pharmacology 318
MICAD NBK23159 (Kappa opioid receptor)
Reactome R-RNO-375276 (Peptide ligand-binding receptors.)
R-RNO-418594 (G alpha (i) signalling events.)
UniProt P34975

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000452 (Kappa_opi_rcpt.)
IPR001418 (Opioid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)