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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3607
Target Type SINGLE PROTEIN
Preferred Name Glutamate receptor ionotropic kainate 2
Synonyms GluK2 | GluR-6 | GluR6 | Glur6 | Glutamate receptor 6 | Glutamate receptor ionotropic, kainate 2 | Grik2
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > kainate receptor

Target Components

Component Description Relationship Accession
Glutamate receptor ionotropic, kainate 2 SINGLE PROTEIN P42260

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038481 Ionotropic glutamate receptor kainate 2/5 PROTEIN COMPLEX
CHEMBL2094119 Glutamate receptor ionotropic, kainate PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0008328 (ionotropic glutamate receptor complex)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0032839 (dendrite cytoplasm)
GO:0032983 (kainate selective glutamate receptor complex)
GO:0042734 (presynaptic membrane)
GO:0043025 (neuronal cell body)
GO:0043195 (terminal bouton)
GO:0043204 (perikaryon)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004970 (ionotropic glutamate receptor activity)
GO:0005216 (ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0005515 (protein binding)
GO:0008066 (glutamate receptor activity)
GO:0015277 (kainate selective glutamate receptor activity)
GO:0030165 (PDZ domain binding)
GO:0031624 (ubiquitin conjugating enzyme binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0038023 (signaling receptor activity)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0001662 (behavioral fear response)
GO:0006811 (ion transport)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006886 (intracellular protein transport)
GO:0007268 (chemical synaptic transmission)
GO:0019228 (neuronal action potential)
GO:0034220 (ion transmembrane transport)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0035249 (synaptic transmission, glutamatergic)
GO:0042391 (regulation of membrane potential)
GO:0043113 (receptor clustering)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0043525 (positive regulation of neuron apoptotic process)
GO:0046328 (regulation of JNK cascade)
GO:0048169 (regulation of long-term neuronal synaptic plasticity)
GO:0048172 (regulation of short-term neuronal synaptic plasticity)
GO:0050804 (modulation of synaptic transmission)
GO:0050806 (positive regulation of synaptic transmission)
GO:0051402 (neuron apoptotic process)
GO:0051967 (negative regulation of synaptic transmission, glutamatergic)
GO:0060079 (excitatory postsynaptic potential)
GO:0060080 (inhibitory postsynaptic potential)

Target Cross References - Protein

canSAR P42260
IntAct P42260
Guide to Pharmacology 451
Reactome R-RNO-451307 (Activation of Na-permeable kainate receptors.)
R-RNO-451308 (Activation of Ca-permeable Kainate Receptor.)
UniProt P42260

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10613 (Lig_chan-Glu_bd)

Target Cross References - Structure

PDBe 1S50 1S7Y 1S9T 1SD3 1TT1 1YAE 2I0B 2I0C 2XXR 2XXT 2XXU 2XXV 2XXW 2XXX 2XXY 3G3F 3G3G 3G3H 3G3I 3G3J 3G3K 3H6G 3H6H 3QLT More...
CREDO 1S50 1S7Y 1S9T 1SD3 1TT1 1YAE 2I0B 2I0C 2XXR 2XXT 2XXU 2XXV 2XXW 2XXX 2XXY 3G3F 3G3G 3G3H 3G3I 3G3J 3G3K 3H6G 3H6H 3QLT More...
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