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Target Report Card

Target Name and Classification

Target ID CHEMBL3604
Preferred Name Protein kinase C gamma
Synonyms PKC-gamma | Pkcc | Pkcg | Prkcc | Prkcg | Protein kinase C gamma type
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pkc family > agc protein kinase pkc alpha subfamily

Target Components

Component Description Relationship Accession
Protein kinase C gamma type SINGLE PROTEIN P63319

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094266 Protein kinase C (PKC) PROTEIN FAMILY
CHEMBL2097168 Protein kinase C, PKC; classical PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO:0045202 (synapse)
GO:0048471 (perinuclear region of cytoplasm)
GO:0097060 (synaptic membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004697 (protein kinase C activity)
GO:0004698 (calcium-dependent protein kinase C activity)
GO:0004712 (protein serine/threonine/tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008270 (zinc ion binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007268 (chemical synaptic transmission)
GO:0007611 (learning or memory)
GO:0007635 (chemosensory behavior)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0031397 (negative regulation of protein ubiquitination)
GO:0032095 (regulation of response to food)
GO:0032425 (positive regulation of mismatch repair)
GO:0035556 (intracellular signal transduction)
GO:0042177 (negative regulation of protein catabolic process)
GO:0042752 (regulation of circadian rhythm)
GO:0043278 (response to morphine)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0046777 (protein autophosphorylation)
GO:0048265 (response to pain)
GO:0048511 (rhythmic process)
GO:0050764 (regulation of phagocytosis)
GO:0060384 (innervation)
GO:1901799 (negative regulation of proteasomal protein catabolic process)
GO:1990911 (response to psychosocial stress)

Target Cross References - Protein

canSAR P63319
IntAct P63319
Reactome R-RNO-111933 (Calmodulin induced events.)
R-RNO-114516 (Disinhibition of SNARE formation.)
R-RNO-416993 (Trafficking of GluR2-containing AMPA receptors.)
R-RNO-5099900 (WNT5A-dependent internalization of FZD4.)
R-RNO-76005 (Response to elevated platelet cytosolic Ca2+.)
UniProt P05697 P63319 Q5FWS3

Target Cross References - Domain

InterPro IPR000008 (C2_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR002219 (PE/DAG-bd.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR014375 (Protein_kinase_C_a/b/g.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
IPR020454 (DAG/PE-bd.)
IPR035892 (C2_domain_sf.)
Pfam PF00069 (Pkinase)
PF00130 (C1_1)
PF00168 (C2)
PF00433 (Pkinase_C)