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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3589
Target Type SINGLE PROTEIN
Preferred Name Adenosine kinase
Synonyms ADK | AK | Adenosine 5'-phosphotransferase | Adenosine kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Adenosine kinase SINGLE PROTEIN P55263

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000156110
Ensembl ENSG00000156110
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004001 (adenosine kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
GO:0044822 (poly(A) RNA binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006166 (purine ribonucleoside salvage)
GO:0006167 (AMP biosynthetic process)
GO:0006175 (dATP biosynthetic process)
GO:0009156 (ribonucleoside monophosphate biosynthetic process)
GO:0010613 (positive regulation of cardiac muscle hypertrophy)
GO:0016310 (phosphorylation)
GO:0032922 (circadian regulation of gene expression)
GO:0042102 (positive regulation of T cell proliferation)
GO:0043101 (purine-containing compound salvage)
GO:0044209 (AMP salvage)
GO:0044342 (type B pancreatic cell proliferation)
GO:0046085 (adenosine metabolic process)
Wikipedia ADK_(gene)

Target Cross References - Protein

canSAR P55263
CGD Hypermethioninemia due to adenosine kinase deficiency
Human Protein Atlas ENSG00000156110
IntAct P55263
Guide to Pharmacology 1231
Open Targets ENSG00000156110
PharmGKB PA24579
Pharos P55263 (Tchem)
Reactome R-HSA-74217 (Purine salvage.)
UniProt B7Z783 B7Z800 O00741 O00742 P55263 Q16710 Q5JQ10 Q5JQ11 Q9BTN2

Target Cross References - Domain

InterPro IPR001805 (Adenokinase.)
IPR002173 (Carboh/pur_kinase_PfkB_CS.)
IPR011611 (PfkB_dom.)
IPR029056 (Ribokinase-like.)
Pfam PF00294 (PfkB)

Target Cross References - Structure

PDBe 1BX4 2I6A 2I6B 4O1L
CREDO 1BX4 2I6A 2I6B 4O1L
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