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Target Report Card

Target Name and Classification

Target ID CHEMBL3571
Preferred Name Cannabinoid CB1 receptor
Synonyms Brain-type cannabinoid receptor | CB-R | CB1 | Cannabinoid receptor 1 | Cnr1 | Skr6
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > cannabinoid receptor

Target Components

Component Description Relationship Accession
Cannabinoid receptor 1 SINGLE PROTEIN P20272

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111385 Cannabinoid receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030426 (growth cone)
GO:0042734 (presynaptic membrane)
GO:0042995 (cell projection)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0045121 (membrane raft)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004949 (cannabinoid receptor activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO Biological Process GO:0002866 (positive regulation of acute inflammatory response to antigenic stimulus)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007283 (spermatogenesis)
GO:0007413 (axonal fasciculation)
GO:0007568 (aging)
GO:0007584 (response to nutrient)
GO:0007611 (learning or memory)
GO:0007613 (memory)
GO:0010976 (positive regulation of neuron projection development)
GO:0019216 (regulation of lipid metabolic process)
GO:0019233 (sensory perception of pain)
GO:0031622 (positive regulation of fever generation)
GO:0031999 (negative regulation of fatty acid beta-oxidation)
GO:0032228 (regulation of synaptic transmission, GABAergic)
GO:0032496 (response to lipopolysaccharide)
GO:0033004 (negative regulation of mast cell activation)
GO:0033602 (negative regulation of dopamine secretion)
GO:0035094 (response to nicotine)
GO:0038171 (cannabinoid signaling pathway)
GO:0042220 (response to cocaine)
GO:0042593 (glucose homeostasis)
GO:0043065 (positive regulation of apoptotic process)
GO:0043271 (negative regulation of ion transport)
GO:0043278 (response to morphine)
GO:0045471 (response to ethanol)
GO:0045759 (negative regulation of action potential)
GO:0045776 (negative regulation of blood pressure)
GO:0045777 (positive regulation of blood pressure)
GO:0050796 (regulation of insulin secretion)
GO:0051001 (negative regulation of nitric-oxide synthase activity)
GO:0051966 (regulation of synaptic transmission, glutamatergic)
GO:0060135 (maternal process involved in female pregnancy)
GO:0060259 (regulation of feeding behavior)
GO:0060405 (regulation of penile erection)
GO:0099553 (trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)

Target Cross References - Protein

canSAR P20272
IntAct P20272
Guide to Pharmacology 56
MICAD NBK23051 (Cannabinoid CB1 receptors)
NBK23641 (Cannabinoid CB1receptors)
NBK23643 (Cannabinoid CB1 receptors)
NBK24613 (Cannabinoid CB1receptors)
NBK45618 (Cannabinoid CB1 receptors)
NBK47107 (Cannabinoid CB1 receptors)
NBK47108 (Cannabinoid CB1 receptors)
NBK47333 (Cannabinoid CB1 receptors)
NBK47334 (Cannabinoid CB1 receptors)
NBK47335 (Cannabinoid CB1 receptors)
Reactome R-RNO-373076 (Class A/1 (Rhodopsin-like receptors).)
R-RNO-418594 (G alpha (i) signalling events.)
UniProt P20272

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000810 (Canbinoid_rcpt_1.)
IPR002230 (Cnbnoid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)