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Target Report Card

Target Name and Classification

Target ID CHEMBL3557
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform
Synonyms PP2A subunit A isoform PR65-alpha | PP2A subunit A isoform R1-alpha | Ppp2r1a | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > protein phosphatase regulatory subunit

Target Components

Component Description Relationship Accession
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform SINGLE PROTEIN Q76MZ3

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0000159 (protein phosphatase type 2A complex)
GO:0000775 (chromosome, centromeric region)
GO:0005694 (chromosome)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003823 (antigen binding)
GO:0004722 (protein serine/threonine phosphatase activity)
GO:0005515 (protein binding)
GO:0008601 (protein phosphatase type 2A regulator activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0006461 (protein complex assembly)
GO:0007059 (chromosome segregation)
GO:0007143 (female meiotic division)
GO:0034047 (regulation of protein phosphatase type 2A activity)
GO:0051232 (meiotic spindle elongation)
GO:0051306 (mitotic sister chromatid separation)
GO:0051754 (meiotic sister chromatid cohesion, centromeric)
GO:0070262 (peptidyl-serine dephosphorylation)
GO:1903538 (regulation of meiotic cell cycle process involved in oocyte maturation)
GO:1904886 (beta-catenin destruction complex disassembly)
GO:2001241 (positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)

Target Cross References - Protein

canSAR Q76MZ3
IntAct Q76MZ3
Reactome R-MMU-113501 (Inhibition of replication initiation of damaged DNA by RB1/E2F1.)
R-MMU-1295596 (Spry regulation of FGF signaling.)
R-MMU-180024 (DARPP-32 events.)
R-MMU-195253 (Degradation of beta-catenin by the destruction complex.)
R-MMU-196299 (Beta-catenin phosphorylation cascade.)
R-MMU-198753 (ERK/MAPK targets.)
R-MMU-202670 (ERKs are inactivated.)
R-MMU-2467813 (Separation of Sister Chromatids.)
R-MMU-2500257 (Resolution of Sister Chromatid Cohesion.)
R-MMU-2565942 (Regulation of PLK1 Activity at G2/M Transition.)
R-MMU-2995383 (Initiation of Nuclear Envelope Reformation.)
R-MMU-380259 (Loss of Nlp from mitotic centrosomes.)
R-MMU-380270 (Recruitment of mitotic centrosome proteins and complexes.)
R-MMU-389513 (CTLA4 inhibitory signaling.)
R-MMU-4641262 (Disassembly of the destruction complex and recruitment of AXIN to the membrane.)
R-MMU-5620912 (Anchoring of the basal body to the plasma membrane.)
R-MMU-5663220 (RHO GTPases Activate Formins.)
R-MMU-5673000 (RAF activation.)
R-MMU-5675221 (Negative regulation of MAPK pathway.)
R-MMU-6804757 (Regulation of TP53 Degradation.)
R-MMU-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-MMU-68877 (Mitotic Prometaphase.)
R-MMU-69231 (Cyclin D associated events in G1.)
R-MMU-69273 (Cyclin A/B1 associated events during G2/M transition.)
R-MMU-8854518 (AURKA Activation by TPX2.)
R-MMU-975957 (Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).)
UniProt Q76MZ3

Target Cross References - Domain

InterPro IPR000357 (HEAT.)
IPR011989 (ARM-like.)
IPR016024 (ARM-type_fold.)
IPR021133 (HEAT_type_2.)
IPR031090 (PP2A_A_meta.)
Pfam PF02985 (HEAT)

Target Cross References - Structure

PDBe 2IAE 2PF4 3FGA
CREDO 2IAE 2PF4 3FGA
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