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Target Report Card

Target Name and Classification

Target ID CHEMBL3549
Preferred Name Adenylate cyclase type I
Synonyms AC1 | ADCY1 | ATP pyrophosphate-lyase 1 | Adenylate cyclase type 1 | Adenylate cyclase type I | Adenylyl cyclase 1 | Ca(2+)/calmodulin-activated adenylyl cyclase
Organism Bos taurus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Adenylate cyclase type 1 SINGLE PROTEIN P19754

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0008074 (guanylate cyclase complex, soluble)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0045121 (membrane raft)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004016 (adenylate cyclase activity)
GO:0004383 (guanylate cyclase activity)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0008294 (calcium- and calmodulin-responsive adenylate cyclase activity)
GO:0016829 (lyase activity)
GO:0016849 (phosphorus-oxygen lyase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006171 (cAMP biosynthetic process)
GO:0006182 (cGMP biosynthetic process)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0009190 (cyclic nucleotide biosynthetic process)
GO:0019933 (cAMP-mediated signaling)
GO:0035556 (intracellular signal transduction)
GO:0042752 (regulation of circadian rhythm)
GO:0048511 (rhythmic process)
GO:0071277 (cellular response to calcium ion)
GO:1904322 (cellular response to forskolin)

Target Cross References - Protein

canSAR P19754
UniProt P19754

Target Cross References - Domain

InterPro IPR001054 (A/G_cyclase.)
IPR018297 (A/G_cyclase_CS.)
IPR029787 (Nucleotide_cyclase.)
IPR030672 (Adcy.)
IPR032628 (AC_N.)
Pfam PF00211 (Guanylate_cyc)
PF16214 (AC_N)