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Target Report Card

Target Name and Classification

Target ID CHEMBL3508
Preferred Name Cholecystokinin B receptor
Synonyms CCK-B receptor | CCK-BR | CCK2-R | Cckbr | Cholecystokinin-2 receptor | Gastrin/cholecystokinin type B receptor
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > cholecystokinin receptor

Target Components

Component Description Relationship Accession
Gastrin/cholecystokinin type B receptor SINGLE PROTEIN P30553

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096986 Cholecystokinin receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0015054 (gastrin receptor activity)
GO Biological Process GO:0001821 (histamine secretion)
GO:0002209 (behavioral defense response)
GO:0006915 (apoptotic process)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007586 (digestion)
GO:0008284 (positive regulation of cell proliferation)
GO:0032230 (positive regulation of synaptic transmission, GABAergic)
GO:0032868 (response to insulin)
GO:0044849 (estrous cycle)
GO:0050806 (positive regulation of synaptic transmission)
GO:0051930 (regulation of sensory perception of pain)
GO:0051968 (positive regulation of synaptic transmission, glutamatergic)
GO:0070371 (ERK1 and ERK2 cascade)
GO:0090274 (positive regulation of somatostatin secretion)

Target Cross References - Protein

canSAR P30553
Guide to Pharmacology 77
MICAD NBK23073 (Gastrin/cholecystokinin-2 (CCK-2, CCK-B) receptor)
NBK23124 (Gastrin/cholecystokinin-2 (CCK-2, CCK-B) receptor)
NBK23147 (Gastrin/cholecystokinin-2 (CCK-2, CCK-B) receptor)
NBK23151 (Gastrin/cholecystokinin-2 (CCK-2) receptor)
NBK23171 (Gastrin/cholecystokinin-2 (CCK-2, CCK-B) receptor)
NBK23246 (Gastrin/cholecystokinin-2 (CCK-2, CCK-B) receptor)
NBK23578 (Gastrin/cholecystokinin-2 (CCK-2, CCK-B) receptor)
NBK23628 (Gastrin/cholecystokinin subtype 2 receptor (CCK-2R))
NBK23710 (Gastrin/cholecystokinin-2 (CCK-2) receptor)
NBK24589 (Gastrin/cholecystokinin-2 (CCK-2, CCK-B) receptor)
NBK24601 (Cholecystokinin receptor 2 (CCK2R))
NBK26805 (Gastrin/cholecystokinin-2 (CCK-2) receptor)
NBK66065 (Gastrin/cholecystokinin-2 receptor (CCK2R))
UniProt P30553

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000314 (Gastrin_rcpt.)
IPR009126 (Cholcskin_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)