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Target Report Card

Target Name and Classification

Target ID CHEMBL3502
Preferred Name Glutamate receptor ionotropic, AMPA 1
Synonyms AMPA-selective glutamate receptor 1 | GluA1 | GluR-1 | GluR-A | GluR-K1 | Glur1 | Glutamate receptor 1 | Glutamate receptor ionotropic, AMPA 1 | Gria1
Organism Mus musculus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > ampa receptor

Target Components

Component Description Relationship Accession
Glutamate receptor 1 SINGLE PROTEIN P23818

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096617 Glutamate receptor ionotropic, AMPA PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0008021 (synaptic vesicle)
GO:0008328 (ionotropic glutamate receptor complex)
GO:0009986 (cell surface)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0031594 (neuromuscular junction)
GO:0031901 (early endosome membrane)
GO:0032279 (asymmetric synapse)
GO:0032281 (AMPA glutamate receptor complex)
GO:0032590 (dendrite membrane)
GO:0032591 (dendritic spine membrane)
GO:0032991 (macromolecular complex)
GO:0036477 (somatodendritic compartment)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043197 (dendritic spine)
GO:0043198 (dendritic shaft)
GO:0044308 (axonal spine)
GO:0044309 (neuron spine)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0055037 (recycling endosome)
GO:0055038 (recycling endosome membrane)
GO:0060076 (excitatory synapse)
GO:0097060 (synaptic membrane)
GO:0098794 (postsynapse)
GO:0098839 (postsynaptic density membrane)
GO:0099061 (integral component of postsynaptic density membrane)
GO Molecular Function GO:0001540 (beta-amyloid binding)
GO:0001965 (G-protein alpha-subunit binding)
GO:0004970 (ionotropic glutamate receptor activity)
GO:0004971 (AMPA glutamate receptor activity)
GO:0005216 (ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0005515 (protein binding)
GO:0008022 (protein C-terminus binding)
GO:0008179 (adenylate cyclase binding)
GO:0019901 (protein kinase binding)
GO:0019904 (protein domain specific binding)
GO:0030165 (PDZ domain binding)
GO:0031267 (small GTPase binding)
GO:0031489 (myosin V binding)
GO:0031681 (G-protein beta-subunit binding)
GO:0031698 (beta-2 adrenergic receptor binding)
GO:0038023 (signaling receptor activity)
GO:0042802 (identical protein binding)
GO:0051018 (protein kinase A binding)
GO:0097110 (scaffold protein binding)
GO:0099583 (neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)
GO:1904315 (transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)
GO Biological Process GO:0001919 (regulation of receptor recycling)
GO:0006811 (ion transport)
GO:0007165 (signal transduction)
GO:0007268 (chemical synaptic transmission)
GO:0007616 (long-term memory)
GO:0009636 (response to toxic substance)
GO:0019228 (neuronal action potential)
GO:0031623 (receptor internalization)
GO:0034220 (ion transmembrane transport)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0045838 (positive regulation of membrane potential)
GO:0048167 (regulation of synaptic plasticity)
GO:0050804 (modulation of synaptic transmission)
GO:0050806 (positive regulation of synaptic transmission)
GO:0060078 (regulation of postsynaptic membrane potential)
GO:0060079 (excitatory postsynaptic potential)
GO:0060292 (long term synaptic depression)
GO:0099566 (regulation of postsynaptic cytosolic calcium ion concentration)

Target Cross References - Protein

canSAR P23818
IntAct P23818
Reactome R-MMU-204005 (COPII (Coat Protein 2) Mediated Vesicle Transport.)
R-MMU-399710 (Activation of AMPA receptors.)
R-MMU-399719 (Trafficking of AMPA receptors.)
R-MMU-416993 (Trafficking of GluR2-containing AMPA receptors.)
R-MMU-438066 (Unblocking of NMDA receptor, glutamate binding and activation.)
R-MMU-5694530 (Cargo concentration in the ER.)
R-MMU-8849932 (Synaptic adhesion-like molecules.)
UniProt P23818

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10613 (Lig_chan-Glu_bd)