ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL3465
Preferred Name Sigma opioid receptor
Synonyms Oprs1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma1-receptor | Sigma1R | Sigmar1
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Sigma non-opioid intracellular receptor 1 SINGLE PROTEIN O55242

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095192 Opioid receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005635 (nuclear envelope)
GO:0005637 (nuclear inner membrane)
GO:0005640 (nuclear outer membrane)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005811 (lipid particle)
GO:0005886 (plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030426 (growth cone)
GO:0031410 (cytoplasmic vesicle)
GO:0042995 (cell projection)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004985 (opioid receptor activity)
GO:0005515 (protein binding)
GO:0038023 (signaling receptor activity)
GO:0042802 (identical protein binding)
GO Biological Process GO:0006869 (lipid transport)
GO:0007165 (signal transduction)
GO:0007399 (nervous system development)
GO:0038003 (opioid receptor signaling pathway)
GO:0043523 (regulation of neuron apoptotic process)
GO:0070207 (protein homotrimerization)

Target Cross References - Protein

IntAct O55242
MICAD NBK23028 (Sigma 1 receptor)
NBK23440 (Sigma 1 receptor)
UniProt O55242 Q9JKU9

Target Cross References - Domain

InterPro IPR006716 (ERG2_sigma1_rcpt-like.)
Pfam PF04622 (ERG2_Sigma1R)