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Target Report Card

Target Name and Classification

Target ID CHEMBL3464
Preferred Name Nitric oxide synthase, inducible
Synonyms Inducible NO synthase | Inducible NOS | Inosl | MAC-NOS | Macrophage NOS | NOS type II | Nitric oxide synthase, inducible | Nos2 | Peptidyl-cysteine S-nitrosylase NOS2 | iNOS
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Nitric oxide synthase, inducible SINGLE PROTEIN P29477

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005622 (intracellular)
GO:0005737 (cytoplasm)
GO:0005777 (peroxisome)
GO:0005829 (cytosol)
GO:0030863 (cortical cytoskeleton)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0004517 (nitric-oxide synthase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0010181 (FMN binding)
GO:0016491 (oxidoreductase activity)
GO:0020037 (heme binding)
GO:0034617 (tetrahydrobiopterin binding)
GO:0034618 (arginine binding)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0050660 (flavin adenine dinucleotide binding)
GO Biological Process GO:0001542 (ovulation from ovarian follicle)
GO:0001666 (response to hypoxia)
GO:0006527 (arginine catabolic process)
GO:0006801 (superoxide metabolic process)
GO:0006809 (nitric oxide biosynthetic process)
GO:0006954 (inflammatory response)
GO:0007263 (nitric oxide mediated signal transduction)
GO:0007623 (circadian rhythm)
GO:0010629 (negative regulation of gene expression)
GO:0018119 (peptidyl-cysteine S-nitrosylation)
GO:0031284 (positive regulation of guanylate cyclase activity)
GO:0032310 (prostaglandin secretion)
GO:0032496 (response to lipopolysaccharide)
GO:0035690 (cellular response to drug)
GO:0042127 (regulation of cell proliferation)
GO:0042177 (negative regulation of protein catabolic process)
GO:0042742 (defense response to bacterium)
GO:0045776 (negative regulation of blood pressure)
GO:0045909 (positive regulation of vasodilation)
GO:0050796 (regulation of insulin secretion)
GO:0051712 (positive regulation of killing of cells of other organism)
GO:0055114 (oxidation-reduction process)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071345 (cellular response to cytokine stimulus)
GO:0071346 (cellular response to interferon-gamma)
GO:0071407 (cellular response to organic cyclic compound)
GO:0072604 (interleukin-6 secretion)
GO:0072606 (interleukin-8 secretion)
GO:1900015 (regulation of cytokine production involved in inflammatory response)

Target Cross References - Protein

canSAR P29477
IntAct P29477
MICAD NBK23142 (Inducible nitric oxide synthase (iNOS))
Reactome R-MMU-1222556 (ROS, RNS production in phagocytes.)
R-MMU-392154 (Nitric oxide stimulates guanylate cyclase.)
UniProt O70515 O70516 P29477 Q5SXT3 Q6P6A0 Q8R410

Target Cross References - Domain

InterPro IPR001094 (Flavdoxin-like.)
IPR001433 (OxRdtase_FAD/NAD-bd.)
IPR001709 (Flavoprot_Pyr_Nucl_cyt_Rdtase.)
IPR003097 (FAD-binding_1.)
IPR004030 (NOS_N.)
IPR008254 (Flavodoxin/NO_synth.)
IPR017927 (Fd_Rdtase_FAD-bd.)
IPR017938 (Riboflavin_synthase-like_b-brl.)
IPR023173 (NADPH_Cyt_P450_Rdtase_dom3.)
IPR029039 (Flavoprotein-like_dom.)
Pfam PF00175 (NAD_binding_1)
PF00258 (Flavodoxin_1)
PF00667 (FAD_binding_1)
PF02898 (NO_synthase)

Target Cross References - Structure

PDBe 1DD7 1DF1 1DWV 1DWW 1DWX 1JWJ 1JWK 1M8D 1M8E 1M8H 1M8I 1M9T 1N2N 1NOC 1NOD 1NOS 1QOM 1QW4 1QW5 1R35 1VAF 2BHJ 2NOD 2NOS More...
CREDO 1DD7 1DF1 1DWV 1DWW 1DWX 1JWJ 1JWK 1M8D 1M8E 1M8H 1M8I 1M9T 1N2N 1NOC 1NOD 1NOS 1QOM 1QW4 1QW5 1R35 1VAF 2BHJ 2NOD 2NOS More...