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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3459
Target Type SINGLE PROTEIN
Preferred Name Serotonin 1b (5-HT1b) receptor
Synonyms 5-HT-1B | 5-HT1B | 5-hydroxytryptamine receptor 1B | 5ht1b | Htr1b | Serotonin receptor 1B
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > serotonin receptor

Target Components

Component Description Relationship Accession
5-hydroxytryptamine receptor 1B SINGLE PROTEIN P28564

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094123 Serotonin (5-HT) receptor PROTEIN FAMILY
CHEMBL2095159 Serotonin 1 (5-HT1) receptor PROTEIN FAMILY
CHEMBL3301381 Serotonin 1B/1D receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004993 (G-protein coupled serotonin receptor activity)
GO:0008144 (drug binding)
GO:0051378 (serotonin binding)
GO Biological Process GO:0002031 (G-protein coupled receptor internalization)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007198 (adenylate cyclase-inhibiting serotonin receptor signaling pathway)
GO:0007205 (protein kinase C-activating G-protein coupled receptor signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007610 (behavior)
GO:0007631 (feeding behavior)
GO:0014059 (regulation of dopamine secretion)
GO:0014063 (negative regulation of serotonin secretion)
GO:0030818 (negative regulation of cAMP biosynthetic process)
GO:0032229 (negative regulation of synaptic transmission, GABAergic)
GO:0035690 (cellular response to drug)
GO:0042220 (response to cocaine)
GO:0042310 (vasoconstriction)
GO:0042493 (response to drug)
GO:0042756 (drinking behavior)
GO:0045471 (response to ethanol)
GO:0046849 (bone remodeling)
GO:0050795 (regulation of behavior)
GO:0051385 (response to mineralocorticoid)
GO:0051967 (negative regulation of synaptic transmission, glutamatergic)
GO:0071312 (cellular response to alkaloid)
GO:0071502 (cellular response to temperature stimulus)

Target Cross References - Protein

canSAR P28564
Guide to Pharmacology 2
Reactome R-RNO-390666 (Serotonin receptors.)
R-RNO-418594 (G alpha (i) signalling events.)
UniProt P28564

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR002147 (5HT1B_rcpt.)
IPR002231 (5HT_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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