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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3446
Target Type SINGLE PROTEIN
Preferred Name Serotonin 2a (5-HT2a) receptor
Synonyms 5-HT-2 | 5-HT-2A | 5-hydroxytryptamine receptor 2A | 5HTR2A | HTR2A | Serotonin receptor 2A
Organism Bos taurus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > serotonin receptor

Target Components

Component Description Relationship Accession
5-hydroxytryptamine receptor 2A SINGLE PROTEIN Q75Z89

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016023 (cytoplasmic, membrane-bounded vesicle)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0031410 (cytoplasmic vesicle)
GO:0042995 (cell projection)
GO:0043198 (dendritic shaft)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004993 (G-protein coupled serotonin receptor activity)
GO:0008144 (drug binding)
GO:0051378 (serotonin binding)
GO:0071886 (1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding)
GO Biological Process GO:0006874 (cellular calcium ion homeostasis)
GO:0006939 (smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007202 (activation of phospholipase C activity)
GO:0007210 (serotonin receptor signaling pathway)
GO:0007610 (behavior)
GO:0010513 (positive regulation of phosphatidylinositol biosynthetic process)
GO:0014065 (phosphatidylinositol 3-kinase signaling)
GO:0033674 (positive regulation of kinase activity)
GO:0042493 (response to drug)
GO:0044380 (protein localization to cytoskeleton)
GO:0045600 (positive regulation of fat cell differentiation)
GO:0045821 (positive regulation of glycolytic process)
GO:0046883 (regulation of hormone secretion)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050795 (regulation of behavior)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)

Target Cross References - Protein

canSAR Q75Z89
Reactome R-BTA-390666 (Serotonin receptors.)
R-BTA-416476 (G alpha (q) signalling events.)
UniProt Q75Z89

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000455 (5HT2A_rcpt.)
IPR002231 (5HT_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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