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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3444
Target Type SINGLE PROTEIN
Preferred Name Malate dehydrogenase mitochondrial
Synonyms MDH2 | Malate dehydrogenase, mitochondrial
Organism Sus scrofa
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Malate dehydrogenase, mitochondrial SINGLE PROTEIN P00346

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005739 (mitochondrion)
GO:0005759 (mitochondrial matrix)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0016491 (oxidoreductase activity)
GO:0016615 (malate dehydrogenase activity)
GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
GO:0030060 (L-malate dehydrogenase activity)
GO:0042803 (protein homodimerization activity)
GO:0051087 (chaperone binding)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0006099 (tricarboxylic acid cycle)
GO:0006108 (malate metabolic process)
GO:0006475 (internal protein amino acid acetylation)
GO:0009060 (aerobic respiration)
GO:0019752 (carboxylic acid metabolic process)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

canSAR P00346
IntAct P00346
UniProt P00346 Q95308

Target Cross References - Domain

InterPro IPR001236 (Lactate/malate_DH_N.)
IPR001252 (Malate_DH_AS.)
IPR001557 (L-lactate/malate_DH.)
IPR010097 (Malate_DH_type1.)
IPR015955 (Lactate_DH/Glyco_Ohase_4_C.)
IPR022383 (Lactate/malate_DH_C.)
IPR036291 (NAD(P)-bd_dom_sf.)
Pfam PF00056 (Ldh_1_N)
PF02866 (Ldh_1_C)

Target Cross References - Structure

PDBe 1MLD
CREDO 1MLD
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