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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3442
Target Type SINGLE PROTEIN
Preferred Name Glutamate [NMDA] receptor subunit epsilon 2
Synonyms GluN2B | Glutamate [NMDA] receptor subunit epsilon-2 | Glutamate receptor ionotropic, NMDA 2B | Grin2b | N-methyl D-aspartate receptor subtype 2B | NMDAR2B | NR2B
Organism Mus musculus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > nmda receptor

Target Components

Component Description Relationship Accession
Glutamate receptor ionotropic, NMDA 2B SINGLE PROTEIN Q01097

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885583 Glutamate receptor ionotropic, NMDA 1/NMDA 2B PROTEIN COMPLEX
CHEMBL3832634 Glutamate NMDA receptor PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0008021 (synaptic vesicle)
GO:0009986 (cell surface)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0017146 (NMDA selective glutamate receptor complex)
GO:0030018 (Z disc)
GO:0030054 (cell junction)
GO:0042734 (presynaptic membrane)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043083 (synaptic cleft)
GO:0043195 (terminal bouton)
GO:0043197 (dendritic spine)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0097060 (synaptic membrane)
GO:0097440 (apical dendrite)
GO:0098794 (postsynapse)
GO:0098839 (postsynaptic density membrane)
GO Molecular Function GO:0004970 (ionotropic glutamate receptor activity)
GO:0004972 (NMDA glutamate receptor activity)
GO:0005102 (receptor binding)
GO:0005149 (interleukin-1 receptor binding)
GO:0005216 (ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0005261 (cation channel activity)
GO:0005262 (calcium channel activity)
GO:0005515 (protein binding)
GO:0008013 (beta-catenin binding)
GO:0008144 (drug binding)
GO:0008270 (zinc ion binding)
GO:0016594 (glycine binding)
GO:0016595 (glutamate binding)
GO:0022849 (glutamate-gated calcium ion channel activity)
GO:0031749 (D2 dopamine receptor binding)
GO:0035255 (ionotropic glutamate receptor binding)
GO:0038023 (signaling receptor activity)
GO:0042165 (neurotransmitter binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0050839 (cell adhesion molecule binding)
GO:0097110 (scaffold protein binding)
GO:0099529 (neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)
GO:0099583 (neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)
GO Biological Process GO:0001508 (action potential)
GO:0001662 (behavioral fear response)
GO:0001666 (response to hypoxia)
GO:0001701 (in utero embryonic development)
GO:0001964 (startle response)
GO:0001967 (suckling behavior)
GO:0006811 (ion transport)
GO:0006812 (cation transport)
GO:0006816 (calcium ion transport)
GO:0007268 (chemical synaptic transmission)
GO:0007423 (sensory organ development)
GO:0007611 (learning or memory)
GO:0007612 (learning)
GO:0007613 (memory)
GO:0008306 (associative learning)
GO:0010243 (response to organonitrogen compound)
GO:0010738 (regulation of protein kinase A signaling)
GO:0010942 (positive regulation of cell death)
GO:0014049 (positive regulation of glutamate secretion)
GO:0019722 (calcium-mediated signaling)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0042596 (fear response)
GO:0043113 (receptor clustering)
GO:0043408 (regulation of MAPK cascade)
GO:0045471 (response to ethanol)
GO:0046960 (sensitization)
GO:0048167 (regulation of synaptic plasticity)
GO:0048168 (regulation of neuronal synaptic plasticity)
GO:0048169 (regulation of long-term neuronal synaptic plasticity)
GO:0048266 (behavioral response to pain)
GO:0048511 (rhythmic process)
GO:0050806 (positive regulation of synaptic transmission)
GO:0050966 (detection of mechanical stimulus involved in sensory perception of pain)
GO:0051290 (protein heterotetramerization)
GO:0060078 (regulation of postsynaptic membrane potential)
GO:0060079 (excitatory postsynaptic potential)
GO:0060291 (long-term synaptic potentiation)
GO:0097553 (calcium ion transmembrane import into cytosol)
GO:0098989 (NMDA selective glutamate receptor signaling pathway)
GO:0099566 (regulation of postsynaptic cytosolic calcium ion concentration)
GO:1900273 (positive regulation of long-term synaptic potentiation)
GO:1901216 (positive regulation of neuron death)
GO:1902951 (negative regulation of dendritic spine maintenance)

Target Cross References - Protein

canSAR Q01097
IntAct Q01097
UniProt Q01097 Q9DCB2

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR018884 (NMDAR2_C.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10565 (NMDAR2_C)
PF10613 (Lig_chan-Glu_bd)
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