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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3440
Target Type SINGLE PROTEIN
Preferred Name Beta-1 adrenergic receptor
Synonyms Adrb1 | Adrb1r | Beta-1 adrenergic receptor | Beta-1 adrenoceptor | Beta-1 adrenoreceptor
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Beta-1 adrenergic receptor SINGLE PROTEIN P34971

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111395 Beta-adrenergic receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004940 (beta1-adrenergic receptor activity)
GO:0005057 (receptor signaling protein activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005515 (protein binding)
GO:0030165 (PDZ domain binding)
GO:0031694 (alpha-2A adrenergic receptor binding)
GO:0046982 (protein heterodimerization activity)
GO:0051379 (epinephrine binding)
GO:0051380 (norepinephrine binding)
GO Biological Process GO:0001996 (positive regulation of heart rate by epinephrine-norepinephrine)
GO:0001997 (positive regulation of the force of heart contraction by epinephrine-norepinephrine)
GO:0002024 (diet induced thermogenesis)
GO:0002025 (vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007267 (cell-cell signaling)
GO:0009409 (response to cold)
GO:0030819 (positive regulation of cAMP biosynthetic process)
GO:0031649 (heat generation)
GO:0035556 (intracellular signal transduction)
GO:0040015 (negative regulation of multicellular organism growth)
GO:0042596 (fear response)
GO:0043547 (positive regulation of GTPase activity)
GO:0043950 (positive regulation of cAMP-mediated signaling)
GO:0045823 (positive regulation of heart contraction)
GO:0050873 (brown fat cell differentiation)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)

Target Cross References - Protein

IntAct P34971
Reactome R-MMU-390696 (Adrenoceptors.)
R-MMU-418555 (G alpha (s) signalling events.)
UniProt B2RVY4 P34971

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000507 (ADRB1_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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