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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3439
Target Type SINGLE PROTEIN
Preferred Name Aminopeptidase A
Synonyms AP-A | Aminopeptidase A | CD_antigen=CD249 | Differentiation antigen gp160 | EAP | ENPEP | Glutamyl aminopeptidase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m1 family

Target Components

Component Description Relationship Accession
Glutamyl aminopeptidase SINGLE PROTEIN Q07075

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831223 Aminopeptidase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138792
Ensembl ENSG00000138792
GO Cellular Component GO:0005765 (lysosomal membrane)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005903 (brush border)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0045177 (apical part of cell)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004177 (aminopeptidase activity)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0042277 (peptide binding)
GO:0046872 (metal ion binding)
GO:0070006 (metalloaminopeptidase activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0002003 (angiotensin maturation)
GO:0002005 (angiotensin catabolic process in blood)
GO:0003081 (regulation of systemic arterial blood pressure by renin-angiotensin)
GO:0006508 (proteolysis)
GO:0007267 (cell-cell signaling)
GO:0008283 (cell proliferation)
GO:0016477 (cell migration)
GO:0032835 (glomerulus development)
GO:0043171 (peptide catabolic process)

Target Cross References - Protein

Human Protein Atlas ENSG00000138792
IntAct Q07075
Open Targets ENSG00000138792
PharmGKB PA27790
Reactome R-HSA-2022377 (Metabolism of Angiotensinogen to Angiotensins.)
UniProt Q07075 Q504U2

Target Cross References - Domain

InterPro IPR001930 (Peptidase_M1.)
IPR014782 (Peptidase_M1_N.)
IPR024571 (ERAP1-like_C_dom.)
IPR033508 (Aminopeptidase_A.)
IPR034016 (M1_APN-typ.)
Pfam PF01433 (Peptidase_M1)
PF11838 (ERAP1_C)

Target Cross References - Structure

PDBe 4KX7 4KX8 4KX9 4KXA 4KXB 4KXC 4KXD
CREDO 4KX7 4KX8 4KX9 4KXA 4KXB 4KXC 4KXD
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