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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3437
Preferred Name Amine oxidase, copper containing
Synonyms AOC3 | Copper amine oxidase | HPAO | Membrane primary amine oxidase | SSAO | Semicarbazide-sensitive amine oxidase | VAP-1 | VAP1 | Vascular adhesion protein 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Membrane primary amine oxidase SINGLE PROTEIN Q16853

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2108167 VEPALIMOMAB Amine oxidase, copper containing inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000131471
Ensembl ENSG00000131471
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005769 (early endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005902 (microvillus)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0005507 (copper ion binding)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0008131 (primary amine oxidase activity)
GO:0016491 (oxidoreductase activity)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0048038 (quinone binding)
GO:0052593 (tryptamine:oxygen oxidoreductase (deaminating) activity)
GO:0052594 (aminoacetone:oxygen oxidoreductase(deaminating) activity)
GO:0052595 (aliphatic-amine oxidase activity)
GO:0052596 (phenethylamine:oxygen oxidoreductase (deaminating) activity)
GO Biological Process GO:0006805 (xenobiotic metabolic process)
GO:0006954 (inflammatory response)
GO:0007155 (cell adhesion)
GO:0009308 (amine metabolic process)
GO:0046677 (response to antibiotic)
GO:0055114 (oxidation-reduction process)
Wikipedia AOC3

Target Cross References - Protein

canSAR Q16853
Human Protein Atlas ENSG00000131471
IntAct Q16853
Guide to Pharmacology 2767
Open Targets ENSG00000131471
PharmGKB PA24840
Reactome R-HSA-211945 (Phase 1 - Functionalization of compounds.)
UniProt B2RCI5 K7ESB3 L0L8N9 Q16853 Q45F94

Target Cross References - Domain

InterPro IPR000269 (Cu_amine_oxidase.)
IPR015798 (Cu_amine_oxidase_C.)
IPR015800 (Cu_amine_oxidase_N2.)
IPR015802 (Cu_amine_oxidase_N3.)
IPR016182 (Cu_amine_oxidase_N-reg.)
Pfam PF01179 (Cu_amine_oxid)
PF02727 (Cu_amine_oxidN2)
PF02728 (Cu_amine_oxidN3)

Target Cross References - Structure

PDBe 1PU4 1US1 2C10 2C11 2Y73 2Y74 3ALA 4BTW 4BTX 4BTY
CREDO 1PU4 1US1 2C10 2C11 2Y73 2Y74 3ALA 4BTW 4BTX 4BTY