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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3404
Target Type SINGLE PROTEIN
Preferred Name 6-phosphogluconate dehydrogenase
Synonyms 6-phosphogluconate dehydrogenase, decarboxylating | PGD | PGDH
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
6-phosphogluconate dehydrogenase, decarboxylating SINGLE PROTEIN P52209

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000142657
Ensembl ENSG00000142657
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004616 (phosphogluconate dehydrogenase (decarboxylating) activity)
GO:0016491 (oxidoreductase activity)
GO Biological Process GO:0006098 (pentose-phosphate shunt)
GO:0009051 (pentose-phosphate shunt, oxidative branch)
GO:0019322 (pentose biosynthetic process)
GO:0019521 (D-gluconate metabolic process)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

canSAR P52209
Human Protein Atlas ENSG00000142657
IntAct P52209
Open Targets ENSG00000142657
PharmGKB PA33229
Reactome R-HSA-71336 (Pentose phosphate pathway (hexose monophosphate shunt).)
UniProt A8K2Y9 B4DQJ8 P52209 Q9BWD8

Target Cross References - Domain

InterPro IPR006113 (6PGDH_Gnd/GntZ.)
IPR006114 (6PGDH_C.)
IPR006115 (6PGDH_NADP-bd.)
IPR006183 (Pgluconate_DH.)
IPR006184 (6PGdom_BS.)
IPR008927 (6-PGluconate_DH-like_C_sf.)
IPR013328 (6PGD_dom2.)
IPR036291 (NAD(P)-bd_dom_sf.)
Pfam PF00393 (6PGD)
PF03446 (NAD_binding_2)

Target Cross References - Structure

PDBe 2JKV 4GWG 4GWK
CREDO 2JKV 4GWG 4GWK
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