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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL340
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 3A4
Synonyms 1,8-cineole 2-exo-monooxygenase | Albendazole monooxygenase | Albendazole sulfoxidase | CYP3A3 | CYP3A4 | CYPIIIA3 | CYPIIIA4 | Cholesterol 25-hydroxylase | Cytochrome P450 3A3 | Cytochrome P450 3A4 | Cytochrome P450 HLp | Cytochrome P450 NF-25 | Cytochrome P450-PCN1 | Nifedipine oxidase | Quinine 3-monooxygenase | Taurochenodeoxycholate 6-alpha-hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 3 > cytochrome p450 family 3a > cytochrome p450 3a4

Target Components

Component Description Relationship Accession
Cytochrome P450 3A4 SINGLE PROTEIN P08684

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111472 Cytochrome P450 3A4/3A5 PROTEIN FAMILY
CHEMBL2364675 Cytochrome P450 3A PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL281764 TABIMORELIN Cytochrome P450 3A4 inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000160868
Ensembl ENSG00000160868
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005496 (steroid binding)
GO:0005506 (iron ion binding)
GO:0008395 (steroid hydroxylase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
GO:0019825 (oxygen binding)
GO:0019899 (enzyme binding)
GO:0020037 (heme binding)
GO:0030343 (vitamin D3 25-hydroxylase activity)
GO:0033780 (taurochenodeoxycholate 6alpha-hydroxylase activity)
GO:0034875 (caffeine oxidase activity)
GO:0046872 (metal ion binding)
GO:0047638 (albendazole monooxygenase activity)
GO:0050591 (quinine 3-monooxygenase activity)
GO:0050649 (testosterone 6-beta-hydroxylase activity)
GO:0070330 (aromatase activity)
GO:0070576 (vitamin D 24-hydroxylase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006706 (steroid catabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0008202 (steroid metabolic process)
GO:0008209 (androgen metabolic process)
GO:0009822 (alkaloid catabolic process)
GO:0016098 (monoterpenoid metabolic process)
GO:0017144 (drug metabolic process)
GO:0036378 (calcitriol biosynthetic process from calciol)
GO:0042359 (vitamin D metabolic process)
GO:0042737 (drug catabolic process)
GO:0042738 (exogenous drug catabolic process)
GO:0046483 (heterocycle metabolic process)
GO:0055114 (oxidation-reduction process)
GO:0070989 (oxidative demethylation)

Target Cross References - Protein

canSAR P08684
CGD Drug metabolism, CYP3A4-related
Human Protein Atlas ENSG00000160868
IntAct P08684
Guide to Pharmacology 1337
Open Targets ENSG00000160868
PharmGKB PA130
Reactome R-HSA-211981 (Xenobiotics.)
R-HSA-5423646 (Aflatoxin activation and detoxification.)
UniProt P05184 P08684 Q16757 Q9UK50

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002402 (Cyt_P450_E_grp-II.)
IPR008072 (Cyt_P450_E_CYP3A.)
IPR017972 (Cyt_P450_CS.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 1TQN 1W0E 1W0F 1W0G 2J0D 2V0M 3NXU 3TJS 3UA1 4D6Z 4D75 4D78 4D7D 4I3Q 4I4G 4I4H 4K9T 4K9U 4K9V 4K9W 4K9X 4NY4 5A1P 5A1R More...
CREDO 1TQN 1W0E 1W0F 1W0G 2J0D 2V0M 3NXU 3TJS 3UA1 4D6Z 4D75 4D78 4D7D 4I3Q 4I4G 4I4H 4K9T 4K9U 4K9V 4K9W 4K9X 4NY4 5A1P 5A1R More...
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