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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3399
Target Type SINGLE PROTEIN
Preferred Name Sodium channel protein type II alpha subunit
Synonyms Scn2a | Scn2a1 | Sodium channel protein brain II subunit alpha | Sodium channel protein type 2 subunit alpha | Sodium channel protein type II subunit alpha | Voltage-gated sodium channel subunit alpha Nav1.2
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated sodium channel

Target Components

Component Description Relationship Accession
Sodium channel protein type 2 subunit alpha SINGLE PROTEIN P04775

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095171 Sodium channel alpha subunits; brain (Types I, II, III) PROTEIN FAMILY
CHEMBL3988641 Voltage-gated sodium channel PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0001518 (voltage-gated sodium channel complex)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031226 (intrinsic component of plasma membrane)
GO:0033268 (node of Ranvier)
GO:0034706 (sodium channel complex)
GO:0043005 (neuron projection)
GO:0043194 (axon initial segment)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005248 (voltage-gated sodium channel activity)
GO:0005272 (sodium channel activity)
GO:0005515 (protein binding)
GO:0031402 (sodium ion binding)
GO:0043522 (leucine zipper domain binding)
GO Biological Process GO:0006811 (ion transport)
GO:0006814 (sodium ion transport)
GO:0019228 (neuronal action potential)
GO:0034765 (regulation of ion transmembrane transport)
GO:0035725 (sodium ion transmembrane transport)
GO:0042552 (myelination)
GO:0055085 (transmembrane transport)
GO:0086010 (membrane depolarization during action potential)

Target Cross References - Protein

canSAR P04775
IntAct P04775
Guide to Pharmacology 579
UniProt P04775

Target Cross References - Domain

InterPro IPR000048 (IQ_motif_EF-hand-BS.)
IPR001696 (Na_channel_asu.)
IPR005821 (Ion_trans_dom.)
IPR010526 (Na_trans_assoc.)
IPR024583 (Na_trans_cytopl.)
IPR027359 (Volt_channel_dom_sf.)
Pfam PF00520 (Ion_trans)
PF06512 (Na_trans_assoc)
PF11933 (Na_trans_cytopl)
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