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Target Report Card

Target Name and Classification

Target ID CHEMBL3397
Preferred Name Cytochrome P450 2C9
Synonyms (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | CYP2C10 | CYP2C9 | CYPIIC9 | Cholesterol 25-hydroxylase | Cytochrome P-450MP | Cytochrome P450 2C9 | Cytochrome P450 MP-4 | Cytochrome P450 MP-8 | Cytochrome P450 PB-1 | S-mephenytoin 4-hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 2 > cytochrome p450 family 2c > cytochrome p450 2c9

Target Components

Component Description Relationship Accession
Cytochrome P450 2C9 SINGLE PROTEIN P11712

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138109
Ensembl ENSG00000138109
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008144 (drug binding)
GO:0008392 (arachidonic acid epoxygenase activity)
GO:0008395 (steroid hydroxylase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0019825 (oxygen binding)
GO:0020037 (heme binding)
GO:0034875 (caffeine oxidase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0008202 (steroid metabolic process)
GO:0016098 (monoterpenoid metabolic process)
GO:0017144 (drug metabolic process)
GO:0019373 (epoxygenase P450 pathway)
GO:0019627 (urea metabolic process)
GO:0032787 (monocarboxylic acid metabolic process)
GO:0042737 (drug catabolic process)
GO:0042738 (exogenous drug catabolic process)
GO:0043603 (cellular amide metabolic process)
GO:0055114 (oxidation-reduction process)
GO:0070989 (oxidative demethylation)
GO:0097267 (omega-hydroxylase P450 pathway)
Wikipedia CYP2C9

Target Cross References - Protein

canSAR P11712
CGD Drug metabolism, CYP2C9-related
Human Protein Atlas ENSG00000138109
IntAct P11712
Guide to Pharmacology 1326
Open Targets ENSG00000138109
PharmGKB PA126
Reactome R-HSA-211981 (Xenobiotics.)
R-HSA-211999 (CYP2E1 reactions.)
R-HSA-2142670 (Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).)
R-HSA-2142816 (Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).)
UniProt P11712 P11713 Q16756 Q16872 Q5VX92 Q6IRV8 Q8WW80

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
IPR036396 (Cyt_P450_sf.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 1OG2 1OG5 1R9O 4NZ2 5A5I 5A5J 5K7K 5W0C 5X23 5X24 5XXI
CREDO 1OG2 1OG5 1R9O 4NZ2 5A5I 5A5J 5K7K 5W0C 5X23 5X24 5XXI