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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3396943
Target Type SINGLE PROTEIN
Preferred Name DNA-3-methyladenine glycosylase
Synonyms 3-alkyladenine DNA glycosylase | 3-methyladenine DNA glycosidase | AAG | ADPG | ANPG | DNA-3-methyladenine glycosylase | MID1 | MPG | N-methylpurine-DNA glycosylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
DNA-3-methyladenine glycosylase SINGLE PROTEIN P29372

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000103152
Ensembl ENSG00000103152
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0042645 (mitochondrial nucleoid)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003684 (damaged DNA binding)
GO:0003824 (catalytic activity)
GO:0003905 (alkylbase DNA N-glycosylase activity)
GO:0005515 (protein binding)
GO:0008725 (DNA-3-methyladenine glycosylase activity)
GO:0016787 (hydrolase activity)
GO:0019104 (DNA N-glycosylase activity)
GO:0043916 (DNA-7-methylguanine glycosylase activity)
GO:0052821 (DNA-7-methyladenine glycosylase activity)
GO:0052822 (DNA-3-methylguanine glycosylase activity)
GO Biological Process GO:0006281 (DNA repair)
GO:0006284 (base-excision repair)
GO:0006307 (DNA dealkylation involved in DNA repair)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0045007 (depurination)

Target Cross References - Protein

Human Protein Atlas ENSG00000103152
IntAct P29372
Open Targets ENSG00000103152
Reactome R-HSA-110330 (Recognition and association of DNA glycosylase with site containing an affected purine.)
R-HSA-110331 (Cleavage of the damaged purine.)
R-HSA-110357 (Displacement of DNA glycosylase by APEX1.)
UniProt G5E9E2 P29372 Q13770 Q15275 Q15961 Q5J9I4 Q96BZ6 Q96S33 Q9NNX5

Target Cross References - Domain

InterPro IPR003180 (PurDNA_glycsylse.)
IPR011034 (Formyl_transferase_C-like.)
Pfam PF02245 (Pur_DNA_glyco)

Target Cross References - Structure

PDBe 1BNK 1EWN 1F4R 1F6O 3QI5 3UBY
CREDO 1BNK 1EWN 1F4R 1F6O 3QI5 3UBY
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