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Target Report Card

Target Name and Classification

Target ID CHEMBL3390
Preferred Name cAMP-dependent protein kinase alpha-catalytic subunit
Synonyms PKA C-alpha | Prkaca | cAMP-dependent protein kinase catalytic subunit alpha
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pka family

Target Components

Component Description Relationship Accession
cAMP-dependent protein kinase catalytic subunit alpha SINGLE PROTEIN P27791

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0001669 (acrosomal vesicle)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005929 (cilium)
GO:0005952 (cAMP-dependent protein kinase complex)
GO:0016020 (membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0031514 (motile cilium)
GO:0032991 (macromolecular complex)
GO:0036126 (sperm flagellum)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO:0048471 (perinuclear region of cytoplasm)
GO:0097225 (sperm midpiece)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004691 (cAMP-dependent protein kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0017137 (Rab GTPase binding)
GO:0019901 (protein kinase binding)
GO:0034237 (protein kinase A regulatory subunit binding)
GO:0044877 (macromolecular complex binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0008284 (positive regulation of cell proliferation)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0034605 (cellular response to heat)
GO:0043457 (regulation of cellular respiration)
GO:0051447 (negative regulation of meiotic cell cycle)
GO:0051966 (regulation of synaptic transmission, glutamatergic)

Target Cross References - Protein

canSAR P27791
IntAct P27791
Guide to Pharmacology 1476
UniProt P27791 Q6UA68

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)