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Target Report Card

Target Name and Classification

Target ID CHEMBL339
Target Type SINGLE PROTEIN
Preferred Name Dopamine D2 receptor
Synonyms D(2) dopamine receptor | Dopamine D2 receptor | Drd2
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > dopamine receptor

Target Components

Component Description Relationship Accession
D(2) dopamine receptor SINGLE PROTEIN P61169

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111342 Dopamine receptor D2 and D3 SELECTIVITY GROUP
CHEMBL2097175 Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor SELECTIVITY GROUP
CHEMBL2093868 Dopamine receptor PROTEIN FAMILY
CHEMBL2096910 Dopamine receptors; D1 & D2 SELECTIVITY GROUP
CHEMBL2111406 Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0001669 (acrosomal vesicle)
GO:0005623 (cell)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016328 (lateral plasma membrane)
GO:0030139 (endocytic vesicle)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0030672 (synaptic vesicle membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0036126 (sperm flagellum)
GO:0043197 (dendritic spine)
GO:0043204 (perikaryon)
GO:0043679 (axon terminus)
GO:0060170 (ciliary membrane)
GO:0097730 (non-motile cilium)
GO Molecular Function GO:0001591 (dopamine neurotransmitter receptor activity, coupled via Gi/Go)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004952 (dopamine neurotransmitter receptor activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0035240 (dopamine binding)
GO:0035255 (ionotropic glutamate receptor binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001659 (temperature homeostasis)
GO:0001666 (response to hypoxia)
GO:0001933 (negative regulation of protein phosphorylation)
GO:0001963 (synaptic transmission, dopaminergic)
GO:0001964 (startle response)
GO:0001975 (response to amphetamine)
GO:0001976 (neurological system process involved in regulation of systemic arterial blood pressure)
GO:0002027 (regulation of heart rate)
GO:0002028 (regulation of sodium ion transport)
GO:0002031 (G-protein coupled receptor internalization)
GO:0002052 (positive regulation of neuroblast proliferation)
GO:0002092 (positive regulation of receptor internalization)
GO:0006914 (autophagy)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007195 (adenylate cyclase-inhibiting dopamine receptor signaling pathway)
GO:0007212 (dopamine receptor signaling pathway)
GO:0007270 (neuron-neuron synaptic transmission)
GO:0007409 (axonogenesis)
GO:0007416 (synapse assembly)
GO:0007608 (sensory perception of smell)
GO:0007616 (long-term memory)
GO:0007625 (grooming behavior)
GO:0007626 (locomotory behavior)
GO:0007628 (adult walking behavior)
GO:0007631 (feeding behavior)
GO:0008104 (protein localization)
GO:0008285 (negative regulation of cell proliferation)
GO:0008306 (associative learning)
GO:0008542 (visual learning)
GO:0009416 (response to light stimulus)
GO:0009636 (response to toxic substance)
GO:0010039 (response to iron ion)
GO:0014059 (regulation of dopamine secretion)
GO:0014854 (response to inactivity)
GO:0016055 (Wnt signaling pathway)
GO:0021756 (striatum development)
GO:0021769 (orbitofrontal cortex development)
GO:0021853 (cerebral cortex GABAergic interneuron migration)
GO:0021984 (adenohypophysis development)
GO:0030007 (cellular potassium ion homeostasis)
GO:0030336 (negative regulation of cell migration)
GO:0030432 (peristalsis)
GO:0030534 (adult behavior)
GO:0030900 (forebrain development)
GO:0031223 (auditory behavior)
GO:0032147 (activation of protein kinase activity)
GO:0032228 (regulation of synaptic transmission, GABAergic)
GO:0032467 (positive regulation of cytokinesis)
GO:0032922 (circadian regulation of gene expression)
GO:0033602 (negative regulation of dopamine secretion)
GO:0034776 (response to histamine)
GO:0035094 (response to nicotine)
GO:0035810 (positive regulation of urine volume)
GO:0035815 (positive regulation of renal sodium excretion)
GO:0040018 (positive regulation of multicellular organism growth)
GO:0042220 (response to cocaine)
GO:0042321 (negative regulation of circadian sleep/wake cycle, sleep)
GO:0042417 (dopamine metabolic process)
GO:0042493 (response to drug)
GO:0043266 (regulation of potassium ion transport)
GO:0043278 (response to morphine)
GO:0043408 (regulation of MAPK cascade)
GO:0043473 (pigmentation)
GO:0043666 (regulation of phosphoprotein phosphatase activity)
GO:0045471 (response to ethanol)
GO:0045745 (positive regulation of G-protein coupled receptor protein signaling pathway)
GO:0045776 (negative regulation of blood pressure)
GO:0045824 (negative regulation of innate immune response)
GO:0045840 (positive regulation of mitotic nuclear division)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046676 (negative regulation of insulin secretion)
GO:0046717 (acid secretion)
GO:0048148 (behavioral response to cocaine)
GO:0048149 (behavioral response to ethanol)
GO:0048169 (regulation of long-term neuronal synaptic plasticity)
GO:0048678 (response to axon injury)
GO:0048755 (branching morphogenesis of a nerve)
GO:0050482 (arachidonic acid secretion)
GO:0050709 (negative regulation of protein secretion)
GO:0050769 (positive regulation of neurogenesis)
GO:0050804 (modulation of synaptic transmission)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0051481 (negative regulation of cytosolic calcium ion concentration)
GO:0051584 (regulation of dopamine uptake involved in synaptic transmission)
GO:0051586 (positive regulation of dopamine uptake involved in synaptic transmission)
GO:0051823 (regulation of synapse structural plasticity)
GO:0051898 (negative regulation of protein kinase B signaling)
GO:0051967 (negative regulation of synaptic transmission, glutamatergic)
GO:0060124 (positive regulation of growth hormone secretion)
GO:0060134 (prepulse inhibition)
GO:0060158 (phospholipase C-activating dopamine receptor signaling pathway)
GO:0060160 (negative regulation of dopamine receptor signaling pathway)
GO:0060548 (negative regulation of cell death)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
GO:0090325 (regulation of locomotion involved in locomotory behavior)
GO:1900168 (positive regulation of glial cell-derived neurotrophic factor secretion)
GO:1900273 (positive regulation of long-term synaptic potentiation)
GO:1901386 (negative regulation of voltage-gated calcium channel activity)

Target Cross References - Protein

canSAR P61169
IntAct P61169
Guide to Pharmacology 215
MICAD NBK23086 (D2 dopamine receptors)
NBK23195 (D2 dopamine receptors)
Reactome R-RNO-390651 (Dopamine receptors.)
R-RNO-418594 (G alpha (i) signalling events.)
UniProt P13953 P61169

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000929 (Dopamine_rcpt.)
IPR001922 (Dopamine_D2_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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