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Target Report Card

Target Name and Classification

Target ID CHEMBL3384
Target Type SINGLE PROTEIN
Preferred Name Protein kinase N1
Synonyms PAK-1 | PAK1 | PKN | PKN1 | PRK1 | PRKCL1 | Protease-activated kinase 1 | Protein kinase C-like 1 | Protein kinase C-like PKN | Protein kinase PKN-alpha | Protein-kinase C-related kinase 1 | Serine-threonine protein kinase N | Serine/threonine-protein kinase N1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pkn family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase N1 SINGLE PROTEIN Q16512

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000123143
Ensembl ENSG00000123143
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0030496 (midbody)
GO:0031410 (cytoplasmic vesicle)
GO:0032154 (cleavage furrow)
GO:0032991 (macromolecular complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003682 (chromatin binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004697 (protein kinase C activity)
GO:0005080 (protein kinase C binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0017049 (GTP-Rho binding)
GO:0030374 (ligand-dependent nuclear receptor transcription coactivator activity)
GO:0035402 (histone kinase activity (H3-T11 specific))
GO:0042393 (histone binding)
GO:0042826 (histone deacetylase binding)
GO:0048365 (Rac GTPase binding)
GO:0050681 (androgen receptor binding)
GO Biological Process GO:0001782 (B cell homeostasis)
GO:0001783 (B cell apoptotic process)
GO:0001933 (negative regulation of protein phosphorylation)
GO:0002634 (regulation of germinal center formation)
GO:0002637 (regulation of immunoglobulin production)
GO:0003014 (renal system process)
GO:0006325 (chromatin organization)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006468 (protein phosphorylation)
GO:0006469 (negative regulation of protein kinase activity)
GO:0006972 (hyperosmotic response)
GO:0007165 (signal transduction)
GO:0007257 (activation of JUN kinase activity)
GO:0010631 (epithelial cell migration)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0030889 (negative regulation of B cell proliferation)
GO:0035407 (histone H3-T11 phosphorylation)
GO:0048536 (spleen development)
GO:2000145 (regulation of cell motility)
Wikipedia Protein_kinase_N1

Target Cross References - Protein

canSAR Q16512
Human Protein Atlas ENSG00000123143
IntAct Q16512
Guide to Pharmacology 1520
Open Targets ENSG00000123143
PharmGKB PA33769
Pharos Q16512 (Tchem)
Reactome R-HSA-5625740 (RHO GTPases activate PKNs.)
R-HSA-5625886 (Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.)
UniProt A8K7W5 B2R9R4 B3KVN3 Q15143 Q16512 Q504U4 Q8IUV5 Q9UD44

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR011072 (HR1_rho-bd.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
IPR035892 (C2_domain_sf.)
IPR036274 (HR1_rpt_sf.)
IPR037313 (PKN_HR1_1.)
IPR037317 (PKN1_HR1_2.)
IPR037784 (C2_PKN.)
Pfam PF00069 (Pkinase)
PF00433 (Pkinase_C)
PF02185 (HR1)

Target Cross References - Structure

PDBe 1CXZ 4NKG 4OTD 4OTG 4OTH 4OTI
CREDO 1CXZ 4NKG 4OTD 4OTG 4OTH 4OTI
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