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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL338
Target Type SINGLE PROTEIN
Preferred Name Dopamine transporter
Synonyms DA transporter | DAT | Slc6a3 | Sodium-dependent dopamine transporter | Solute carrier family 6 member 3
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc06 neurotransmitter transporter family

Target Components

Component Description Relationship Accession
Sodium-dependent dopamine transporter SINGLE PROTEIN P23977

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094252 Monoamine transporters; serotonin & dopamine SELECTIVITY GROUP
CHEMBL2095175 Monoamine transporters; Norepininephrine & dopamine SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016600 (flotillin complex)
GO:0030424 (axon)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0098793 (presynapse)
GO Molecular Function GO:0002020 (protease binding)
GO:0005102 (receptor binding)
GO:0005328 (neurotransmitter:sodium symporter activity)
GO:0005329 (dopamine transmembrane transporter activity)
GO:0005330 (dopamine:sodium symporter activity)
GO:0008144 (drug binding)
GO:0008504 (monoamine transmembrane transporter activity)
GO:0015293 (symporter activity)
GO:0032403 (protein complex binding)
GO:0035240 (dopamine binding)
GO:0046872 (metal ion binding)
GO:0047485 (protein N-terminus binding)
GO:0051721 (protein phosphatase 2A binding)
GO Biological Process GO:0006810 (transport)
GO:0006836 (neurotransmitter transport)
GO:0007568 (aging)
GO:0007595 (lactation)
GO:0007608 (sensory perception of smell)
GO:0007626 (locomotory behavior)
GO:0010039 (response to iron ion)
GO:0014070 (response to organic cyclic compound)
GO:0015844 (monoamine transport)
GO:0015872 (dopamine transport)
GO:0021984 (adenohypophysis development)
GO:0035094 (response to nicotine)
GO:0040018 (positive regulation of multicellular organism growth)
GO:0042053 (regulation of dopamine metabolic process)
GO:0042220 (response to cocaine)
GO:0042416 (dopamine biosynthetic process)
GO:0042420 (dopamine catabolic process)
GO:0042493 (response to drug)
GO:0045471 (response to ethanol)
GO:0051583 (dopamine uptake involved in synaptic transmission)
GO:0051591 (response to cAMP)
GO:0060134 (prepulse inhibition)
GO:0072488 (ammonium transmembrane transport)

Target Cross References - Protein

canSAR P23977
IntAct P23977
Guide to Pharmacology 927
MICAD NBK22986 (Dopamine transporter (DAT))
NBK23271 (Dopamine transporter)
NBK23540 (Dopamine transporter)
NBK23712 (Dopamine transporters)
NBK23716 (Dopamine transporter (DAT))
NBK53694 (Dopamine transporter (DAT))
NBK65436 (Dopamine transporter (DAT))
NBK65437 (Dopamine transporter (DAT))
NBK82506 (Dopamine transporter (DAT))
Reactome R-RNO-379401 (Dopamine clearance from the synaptic cleft.)
R-RNO-442660 (Na+/Cl- dependent neurotransmitter transporters.)
UniProt P23977

Target Cross References - Domain

InterPro IPR000175 (Na/ntran_symport.)
IPR002436 (Na/ntran_symport_dopamine.)
Pfam PF00209 (SNF)
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