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Target Report Card

Target Name and Classification

Target ID CHEMBL3372
Preferred Name Serotonin 6 (5-HT6) receptor
Synonyms 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 | Htr6 | ST-B17 | Serotonin receptor 6
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > serotonin receptor

Target Components

Component Description Relationship Accession
5-hydroxytryptamine receptor 6 SINGLE PROTEIN P31388

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094123 Serotonin (5-HT) receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030425 (dendrite)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004993 (G-protein coupled serotonin receptor activity)
GO:0030594 (neurotransmitter receptor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007420 (brain development)
GO:0007612 (learning)
GO:0014050 (negative regulation of glutamate secretion)
GO:0014053 (negative regulation of gamma-aminobutyric acid secretion)
GO:0014054 (positive regulation of gamma-aminobutyric acid secretion)
GO:0014058 (negative regulation of acetylcholine secretion, neurotransmission)
GO:0021795 (cerebral cortex cell migration)
GO:0032008 (positive regulation of TOR signaling)
GO:0032355 (response to estradiol)
GO:0033603 (positive regulation of dopamine secretion)
GO:0042493 (response to drug)
GO:0060291 (long-term synaptic potentiation)
GO:0098664 (G-protein coupled serotonin receptor signaling pathway)

Target Cross References - Protein

canSAR P31388
Guide to Pharmacology 11
Reactome R-RNO-390666 (Serotonin receptors.)
R-RNO-418555 (G alpha (s) signalling events.)
UniProt P31388

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR002232 (5HT6_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)