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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3365
Target Type SINGLE PROTEIN
Preferred Name Neuronal acetylcholine receptor protein alpha-7 subunit
Synonyms Acra7 | Chrna7 | Neuronal acetylcholine receptor subunit alpha-7
Organism Mus musculus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > nicotinic acetylcholine receptor > nicotinic acetylcholine receptor alpha subunit

Target Components

Component Description Relationship Accession
Neuronal acetylcholine receptor subunit alpha-7 SINGLE PROTEIN P49582

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3350222 Neuronal nicotinic acetylcholine receptor PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005892 (acetylcholine-gated channel complex)
GO:0009897 (external side of plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0030426 (growth cone)
GO:0030673 (axolemma)
GO:0032279 (asymmetric synapse)
GO:0042734 (presynaptic membrane)
GO:0043025 (neuronal cell body)
GO:0043197 (dendritic spine)
GO:0043198 (dendritic shaft)
GO:0044853 (plasma membrane raft)
GO:0045121 (membrane raft)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0098793 (presynapse)
GO Molecular Function GO:0001540 (beta-amyloid binding)
GO:0004888 (transmembrane signaling receptor activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0008179 (adenylate cyclase binding)
GO:0015464 (acetylcholine receptor activity)
GO:0015643 (toxic substance binding)
GO:0017081 (chloride channel regulator activity)
GO:0019901 (protein kinase binding)
GO:0022848 (acetylcholine-gated cation channel activity)
GO:0042166 (acetylcholine binding)
GO:0042803 (protein homodimerization activity)
GO:0051117 (ATPase binding)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0001666 (response to hypoxia)
GO:0001933 (negative regulation of protein phosphorylation)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0001988 (positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure)
GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006897 (endocytosis)
GO:0007165 (signal transduction)
GO:0007271 (synaptic transmission, cholinergic)
GO:0007611 (learning or memory)
GO:0007613 (memory)
GO:0008284 (positive regulation of cell proliferation)
GO:0008306 (associative learning)
GO:0009409 (response to cold)
GO:0014061 (regulation of norepinephrine secretion)
GO:0019228 (neuronal action potential)
GO:0030317 (sperm motility)
GO:0032094 (response to food)
GO:0032222 (regulation of synaptic transmission, cholinergic)
GO:0032225 (regulation of synaptic transmission, dopaminergic)
GO:0032691 (negative regulation of interleukin-1 beta production)
GO:0032715 (negative regulation of interleukin-6 production)
GO:0032720 (negative regulation of tumor necrosis factor production)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0034220 (ion transmembrane transport)
GO:0035094 (response to nicotine)
GO:0035095 (behavioral response to nicotine)
GO:0042110 (T cell activation)
GO:0042113 (B cell activation)
GO:0042391 (regulation of membrane potential)
GO:0042698 (ovulation cycle)
GO:0045471 (response to ethanol)
GO:0045766 (positive regulation of angiogenesis)
GO:0048149 (behavioral response to ethanol)
GO:0050727 (regulation of inflammatory response)
GO:0050728 (negative regulation of inflammatory response)
GO:0050804 (modulation of synaptic transmission)
GO:0050808 (synapse organization)
GO:0050890 (cognition)
GO:0050893 (sensory processing)
GO:0051247 (positive regulation of protein metabolic process)
GO:0051823 (regulation of synapse structural plasticity)
GO:0060078 (regulation of postsynaptic membrane potential)
GO:0060079 (excitatory postsynaptic potential)
GO:0060112 (generation of ovulation cycle rhythm)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0095500 (acetylcholine receptor signaling pathway)
GO:0097061 (dendritic spine organization)
GO:0098815 (modulation of excitatory postsynaptic potential)
GO:0140059 (dendrite arborization)
GO:1900273 (positive regulation of long-term synaptic potentiation)
GO:1901214 (regulation of neuron death)
GO:1902004 (positive regulation of beta-amyloid formation)
GO:1902430 (negative regulation of beta-amyloid formation)
GO:1902991 (regulation of amyloid precursor protein catabolic process)
GO:1904645 (response to amyloid-beta)
GO:1905144 (response to acetylcholine)
GO:1905906 (regulation of amyloid fibril formation)
GO:1905920 (positive regulation of CoA-transferase activity)
GO:1905923 (positive regulation of acetylcholine biosynthetic process)
GO:2000463 (positive regulation of excitatory postsynaptic potential)

Target Cross References - Protein

canSAR P49582
IntAct P49582
MICAD NBK23663 (Neuronal alpha-7 nicotinic acetylcholine receptor (nAChR))
NBK51667 (Neuronal alpha-7 nicotinic acetylcholine receptor (nAChR))
NBK51669 (Neuronal alpha-7 nicotinic acetylcholine receptor (nAChR))
NBK51678 (Neuronal alpha-7 nicotinic acetylcholine receptor (nAChR))
Reactome R-MMU-629594 (Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.)
UniProt P49582

Target Cross References - Domain

InterPro IPR002394 (Nicotinic_acetylcholine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR036719 (Neuro-gated_channel_TM_sf.)
IPR036734 (Neur_chan_lig-bd_sf.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)
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