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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3365
Target Type SINGLE PROTEIN
Preferred Name Neuronal acetylcholine receptor protein alpha-7 subunit
Synonyms Acra7 | Chrna7 | Neuronal acetylcholine receptor subunit alpha-7
Organism Mus musculus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > nicotinic acetylcholine receptor > nicotinic acetylcholine receptor alpha subunit

Target Components

Component Description Relationship Accession
Neuronal acetylcholine receptor subunit alpha-7 SINGLE PROTEIN P49582

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3350222 Neuronal nicotinic acetylcholine receptor PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005892 (acetylcholine-gated channel complex)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0030054 (cell junction)
GO:0030673 (axolemma)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0001540 (beta-amyloid binding)
GO:0004889 (acetylcholine-activated cation-selective channel activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005515 (protein binding)
GO:0015464 (acetylcholine receptor activity)
GO:0015643 (toxic substance binding)
GO:0017081 (chloride channel regulator activity)
GO:0022848 (acetylcholine-gated cation channel activity)
GO:0042166 (acetylcholine binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0001666 (response to hypoxia)
GO:0001988 (positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006897 (endocytosis)
GO:0007165 (signal transduction)
GO:0007271 (synaptic transmission, cholinergic)
GO:0007613 (memory)
GO:0008284 (positive regulation of cell proliferation)
GO:0008306 (associative learning)
GO:0014061 (regulation of norepinephrine secretion)
GO:0030317 (sperm motility)
GO:0032094 (response to food)
GO:0032225 (regulation of synaptic transmission, dopaminergic)
GO:0032691 (negative regulation of interleukin-1 beta production)
GO:0032715 (negative regulation of interleukin-6 production)
GO:0032720 (negative regulation of tumor necrosis factor production)
GO:0034220 (ion transmembrane transport)
GO:0035094 (response to nicotine)
GO:0035095 (behavioral response to nicotine)
GO:0042110 (T cell activation)
GO:0042113 (B cell activation)
GO:0042391 (regulation of membrane potential)
GO:0042698 (ovulation cycle)
GO:0045471 (response to ethanol)
GO:0045766 (positive regulation of angiogenesis)
GO:0048149 (behavioral response to ethanol)
GO:0050727 (regulation of inflammatory response)
GO:0050728 (negative regulation of inflammatory response)
GO:0050890 (cognition)
GO:0060112 (generation of ovulation cycle rhythm)
GO:0098655 (cation transmembrane transport)
GO:0099565 (chemical synaptic transmission, postsynaptic)

Target Cross References - Protein

canSAR P49582
IntAct P49582
MICAD NBK23663 (Neuronal alpha-7 nicotinic acetylcholine receptor (nAChR))
NBK51667 (Neuronal alpha-7 nicotinic acetylcholine receptor (nAChR))
NBK51669 (Neuronal alpha-7 nicotinic acetylcholine receptor (nAChR))
NBK51678 (Neuronal alpha-7 nicotinic acetylcholine receptor (nAChR))
Reactome R-MMU-629594 (Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.)
UniProt P49582

Target Cross References - Domain

InterPro IPR002394 (Nicotinic_acetylcholine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR027361 (Acetylcholine_rcpt_TM.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)
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