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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3359
Target Type SINGLE PROTEIN
Preferred Name Formyl peptide receptor 1
Synonyms FPR | FPR1 | N-formyl peptide receptor | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > n-formyl methionyl peptide receptor > n-formyl methionyl peptide receptor

Target Components

Component Description Relationship Accession
fMet-Leu-Phe receptor SINGLE PROTEIN P21462

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038479 fMet-Leu-Phe receptor 1/2 PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171051
Ensembl ENSG00000171051
GO Cellular Component GO:0005768 (endosome)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004872 (receptor activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004982 (N-formyl peptide receptor activity)
GO:0005515 (protein binding)
GO:0050786 (RAGE receptor binding)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0006928 (movement of cell or subcellular component)
GO:0006935 (chemotaxis)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007263 (nitric oxide mediated signal transduction)
Wikipedia Formyl_peptide_receptor_1

Target Cross References - Protein

canSAR P21462
Human Protein Atlas ENSG00000171051
IntAct P21462
Guide to Pharmacology 222
Open Targets ENSG00000171051
PharmGKB PA28244
Pharos P21462 (Tchem)
Reactome R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-444473 (Formyl peptide receptors bind formyl peptides and many other ligands.)
R-HSA-6783783 (Interleukin-10 signaling.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt P21462 Q14939 Q7Z6A4 Q86U52 Q9NS48

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000826 (Formyl_rcpt-rel.)
IPR017452 (GPCR_Rhodpsn_7TM.)
IPR027345 (Formyl_pep_1_rcpt.)
Pfam PF00001 (7tm_1)
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