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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3358
Target Type SINGLE PROTEIN
Preferred Name Monoamine oxidase A
Synonyms Amine oxidase [flavin-containing] A | MAO-A | Maoa | Monoamine oxidase type A
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Amine oxidase [flavin-containing] A SINGLE PROTEIN P21396

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095196 Monoamine oxidase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0008131 (primary amine oxidase activity)
GO:0016491 (oxidoreductase activity)
GO:0050660 (flavin adenine dinucleotide binding)
GO:0051378 (serotonin binding)
GO Biological Process GO:0006584 (catecholamine metabolic process)
GO:0042135 (neurotransmitter catabolic process)
GO:0042424 (catecholamine catabolic process)
GO:0042428 (serotonin metabolic process)
GO:0042443 (phenylethylamine metabolic process)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

canSAR P21396
MICAD NBK23217 (Monoamine oxidase A (MAO-A))
UniProt P21396 Q63817

Target Cross References - Domain

InterPro IPR001613 (Flavin_amine_oxidase.)
IPR002937 (Amino_oxidase.)
IPR016040 (NAD(P)-bd_dom.)
IPR023753 (FAD/NAD-binding_dom.)
Pfam PF01593 (Amino_oxidase)

Target Cross References - Structure

PDBe 1O5W
CREDO 1O5W
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