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Target Report Card

Target Name and Classification

Target ID CHEMBL3357
Target Type SINGLE PROTEIN
Preferred Name Interleukin-1 receptor-associated kinase 1
Synonyms IRAK | IRAK-1 | IRAK1 | Interleukin-1 receptor-associated kinase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase irak family

Target Components

Component Description Relationship Accession
Interleukin-1 receptor-associated kinase 1 SINGLE PROTEIN P51617

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000184216
Ensembl ENSG00000184216
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005811 (lipid particle)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0010008 (endosome membrane)
GO:0016020 (membrane)
GO:0045323 (interleukin-1 receptor complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004704 (NF-kappaB-inducing kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0031072 (heat shock protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0001959 (regulation of cytokine-mediated signaling pathway)
GO:0002224 (toll-like receptor signaling pathway)
GO:0002376 (immune system process)
GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway)
GO:0007250 (activation of NF-kappaB-inducing kinase activity)
GO:0007254 (JNK cascade)
GO:0007568 (aging)
GO:0016032 (viral process)
GO:0016310 (phosphorylation)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0031663 (lipopolysaccharide-mediated signaling pathway)
GO:0032088 (negative regulation of NF-kappaB transcription factor activity)
GO:0032481 (positive regulation of type I interferon production)
GO:0032496 (response to lipopolysaccharide)
GO:0034134 (toll-like receptor 2 signaling pathway)
GO:0034142 (toll-like receptor 4 signaling pathway)
GO:0034162 (toll-like receptor 9 signaling pathway)
GO:0034605 (cellular response to heat)
GO:0043066 (negative regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0045087 (innate immune response)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0046777 (protein autophosphorylation)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051259 (protein oligomerization)
GO:0060337 (type I interferon signaling pathway)
GO:0070423 (nucleotide-binding oligomerization domain containing signaling pathway)
GO:0070498 (interleukin-1-mediated signaling pathway)
GO:0070555 (response to interleukin-1)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071456 (cellular response to hypoxia)
Wikipedia IRAK1

Target Cross References - Protein

canSAR P51617
Human Protein Atlas ENSG00000184216
IntAct P51617
Guide to Pharmacology 2042
Open Targets ENSG00000184216
PharmGKB PA29912
Pharos P51617 (Tchem)
Reactome R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-166058 (MyD88:Mal cascade initiated on plasma membrane.)
R-HSA-168638 (NOD1/2 Signaling Pathway.)
R-HSA-209543 (p75NTR recruits signalling complexes.)
R-HSA-209560 (NF-kB is activated and signals survival.)
R-HSA-445989 (TAK1 activates NFkB by phosphorylation and activation of IKKs complex.)
R-HSA-450302 (activated TAK1 mediates p38 MAPK activation.)
R-HSA-450321 (JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-9020702 (Interleukin-1 signaling.)
R-HSA-937039 (IRAK1 recruits IKK complex.)
R-HSA-975110 (TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.)
R-HSA-975138 (TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.)
R-HSA-975144 (IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.)
R-HSA-975155 (MyD88 dependent cascade initiated on endosome.)
R-HSA-975871 (MyD88 cascade initiated on plasma membrane.)
UniProt D3DWW3 D3DWW4 P51617 Q7Z5V4 Q96C06 Q96RL2

Target Cross References - Domain

InterPro IPR000488 (Death_domain.)
IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR011029 (DEATH-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR035533 (Death_IRAK1.)
IPR035536 (IRAK1.)
Pfam PF00069 (Pkinase)
PF00531 (Death)

Target Cross References - Structure

PDBe 6BFN
CREDO 6BFN
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