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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3356
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 1A2
Synonyms CYP1A2 | CYPIA2 | Cholesterol 25-hydroxylase | Cytochrome P(3)450 | Cytochrome P450 1A2 | Cytochrome P450 4 | Cytochrome P450-P3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 1 > cytochrome p450 family 1a > cytochrome p450 1a2

Target Components

Component Description Relationship Accession
Cytochrome P450 1A2 SINGLE PROTEIN P05177

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3544905 Cytochrome P450 1A PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000140505
Ensembl ENSG00000140505
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0009055 (electron carrier activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
GO:0019825 (oxygen binding)
GO:0019899 (enzyme binding)
GO:0020037 (heme binding)
GO:0032451 (demethylase activity)
GO:0034875 (caffeine oxidase activity)
GO:0046872 (metal ion binding)
GO:0070330 (aromatase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006706 (steroid catabolic process)
GO:0006725 (cellular aromatic compound metabolic process)
GO:0006778 (porphyrin-containing compound metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0008202 (steroid metabolic process)
GO:0009403 (toxin biosynthetic process)
GO:0009404 (toxin metabolic process)
GO:0009791 (post-embryonic development)
GO:0009820 (alkaloid metabolic process)
GO:0010033 (response to organic substance)
GO:0010468 (regulation of gene expression)
GO:0014070 (response to organic cyclic compound)
GO:0016098 (monoterpenoid metabolic process)
GO:0017144 (drug metabolic process)
GO:0018894 (dibenzo-p-dioxin metabolic process)
GO:0019373 (epoxygenase P450 pathway)
GO:0030324 (lung development)
GO:0032259 (methylation)
GO:0032355 (response to estradiol)
GO:0032496 (response to lipopolysaccharide)
GO:0032787 (monocarboxylic acid metabolic process)
GO:0035902 (response to immobilization stress)
GO:0042493 (response to drug)
GO:0042737 (drug catabolic process)
GO:0042738 (exogenous drug catabolic process)
GO:0045333 (cellular respiration)
GO:0046483 (heterocycle metabolic process)
GO:0050665 (hydrogen peroxide biosynthetic process)
GO:0055114 (oxidation-reduction process)
GO:0070989 (oxidative demethylation)
GO:0071276 (cellular response to cadmium ion)
GO:0071615 (oxidative deethylation)
GO:0097267 (omega-hydroxylase P450 pathway)
Wikipedia CYP1A2

Target Cross References - Protein

canSAR P05177
CGD CYP1A2-related drug metabolism
Human Protein Atlas ENSG00000140505
Guide to Pharmacology 1319
Open Targets ENSG00000140505
PharmGKB PA27093
Reactome R-HSA-156581 (Methylation.)
R-HSA-211957 (Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2.)
R-HSA-2142670 (Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).)
R-HSA-2142816 (Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).)
R-HSA-5423646 (Aflatoxin activation and detoxification.)
UniProt P05177 Q16754 Q6NWU5 Q9BXX7 Q9UK49

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR008066 (Cyt_P450_E_grp-I_CYP1.)
IPR017972 (Cyt_P450_CS.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 2HI4
CREDO 2HI4
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