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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3351
Target Type SINGLE PROTEIN
Preferred Name Acetyl-CoA carboxylase 1
Synonyms ACAC | ACACA | ACC-alpha | ACC1 | ACC1 | ACCA | Acetyl-CoA carboxylase 1 | Biotin carboxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Acetyl-CoA carboxylase 1 SINGLE PROTEIN Q13085

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000275176 ENSG00000278540
Ensembl ENSG00000275176 ENSG00000278540
GO Cellular Component GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0015629 (actin cytoskeleton)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003824 (catalytic activity)
GO:0003989 (acetyl-CoA carboxylase activity)
GO:0004075 (biotin carboxylase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016874 (ligase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001894 (tissue homeostasis)
GO:0006084 (acetyl-CoA metabolic process)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006768 (biotin metabolic process)
GO:0006853 (carnitine shuttle)
GO:0008152 (metabolic process)
GO:0031325 (positive regulation of cellular metabolic process)
GO:0035338 (long-chain fatty-acyl-CoA biosynthetic process)
GO:0044268 (multicellular organismal protein metabolic process)
GO:0051289 (protein homotetramerization)
GO:0055088 (lipid homeostasis)
GO:0071380 (cellular response to prostaglandin E stimulus)
GO:2001295 (malonyl-CoA biosynthetic process)
Wikipedia ACACA

Target Cross References - Protein

canSAR Q13085
Human Protein Atlas ENSG00000275176 ENSG00000278540
IntAct Q13085
Guide to Pharmacology 1263
Open Targets ENSG00000275176 ENSG00000278540
PharmGKB PA24421
Reactome R-HSA-163765 (ChREBP activates metabolic gene expression.)
R-HSA-196780 (Biotin transport and metabolism.)
R-HSA-200425 (Import of palmitoyl-CoA into the mitochondrial matrix.)
R-HSA-2426168 (Activation of gene expression by SREBF (SREBP).)
R-HSA-3371599 (Defective HLCS causes multiple carboxylase deficiency.)
R-HSA-75105 (Fatty Acyl-CoA Biosynthesis.)
UniProt B2RP68 Q13085 Q6KEV6 Q6XDA8 Q7Z2G8 Q7Z561 Q7Z563 Q7Z564 Q86WB2 Q86WB3

Target Cross References - Domain

InterPro IPR000022 (Carboxyl_trans.)
IPR000089 (Biotin_lipoyl.)
IPR001882 (Biotin_BS.)
IPR005479 (CbamoylP_synth_lsu-like_ATP-bd.)
IPR005481 (BC-like_N.)
IPR005482 (Biotin_COase_C.)
IPR011053 (Single_hybrid_motif.)
IPR011054 (Rudment_hybrid_motif.)
IPR011761 (ATP-grasp.)
IPR011762 (COA_CT_N.)
IPR011763 (COA_CT_C.)
IPR011764 (Biotin_carboxylation_dom.)
IPR013537 (AcCoA_COase_cen.)
IPR013815 (ATP_grasp_subdomain_1.)
IPR013816 (ATP_grasp_subdomain_2.)
IPR016185 (PreATP-grasp_dom.)
IPR029045 (ClpP/crotonase-like_dom.)
Pfam PF00289 (Biotin_carb_N)
PF00364 (Biotin_lipoyl)
PF01039 (Carboxyl_trans)
PF02785 (Biotin_carb_C)
PF02786 (CPSase_L_D2)
PF08326 (ACC_central)

Target Cross References - Structure

PDBe 2YL2 3COJ 4ASI
CREDO 2YL2 3COJ 4ASI
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