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Target Report Card

Target Name and Classification

Target ID CHEMBL3337
Preferred Name Vascular endothelial growth factor receptor 2
Synonyms CD_antigen=CD309 | FLK-1 | Fetal liver kinase 1 | Flk-1 | Flk1 | Kdr | Kinase NYK | Protein-tyrosine kinase receptor flk-1 | VEGFR-2 | Vascular endothelial growth factor receptor 2
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase vegfr family

Target Components

Component Description Relationship Accession
Vascular endothelial growth factor receptor 2 SINGLE PROTEIN P35918

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0031410 (cytoplasmic vesicle)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0045121 (membrane raft)
GO:0071944 (cell periphery)
GO:0097443 (sorting endosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005021 (vascular endothelial growth factor-activated receptor activity)
GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019838 (growth factor binding)
GO:0038085 (vascular endothelial growth factor binding)
GO:0042802 (identical protein binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001541 (ovarian follicle development)
GO:0001570 (vasculogenesis)
GO:0001666 (response to hypoxia)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0001936 (regulation of endothelial cell proliferation)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0001945 (lymph vessel development)
GO:0002042 (cell migration involved in sprouting angiogenesis)
GO:0002053 (positive regulation of mesenchymal cell proliferation)
GO:0003157 (endocardium development)
GO:0003158 (endothelium development)
GO:0003416 (endochondral bone growth)
GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007275 (multicellular organism development)
GO:0008284 (positive regulation of cell proliferation)
GO:0008360 (regulation of cell shape)
GO:0008584 (male gonad development)
GO:0010595 (positive regulation of endothelial cell migration)
GO:0010629 (negative regulation of gene expression)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0016239 (positive regulation of macroautophagy)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030097 (hemopoiesis)
GO:0030154 (cell differentiation)
GO:0030324 (lung development)
GO:0030335 (positive regulation of cell migration)
GO:0030513 (positive regulation of BMP signaling pathway)
GO:0030949 (positive regulation of vascular endothelial growth factor receptor signaling pathway)
GO:0032008 (positive regulation of TOR signaling)
GO:0035162 (embryonic hemopoiesis)
GO:0035584 (calcium-mediated signaling using intracellular calcium source)
GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
GO:0038033 (positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042493 (response to drug)
GO:0043066 (negative regulation of apoptotic process)
GO:0043129 (surfactant homeostasis)
GO:0043410 (positive regulation of MAPK cascade)
GO:0043491 (protein kinase B signaling)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0043536 (positive regulation of blood vessel endothelial cell migration)
GO:0045165 (cell fate commitment)
GO:0045446 (endothelial cell differentiation)
GO:0045601 (regulation of endothelial cell differentiation)
GO:0045766 (positive regulation of angiogenesis)
GO:0046777 (protein autophosphorylation)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048170 (positive regulation of long-term neuronal synaptic plasticity)
GO:0048286 (lung alveolus development)
GO:0048469 (cell maturation)
GO:0048597 (post-embryonic camera-type eye morphogenesis)
GO:0048754 (branching morphogenesis of an epithelial tube)
GO:0048812 (neuron projection morphogenesis)
GO:0050679 (positive regulation of epithelial cell proliferation)
GO:0050850 (positive regulation of calcium-mediated signaling)
GO:0050927 (positive regulation of positive chemotaxis)
GO:0051770 (positive regulation of nitric-oxide synthase biosynthetic process)
GO:0051894 (positive regulation of focal adhesion assembly)
GO:0051901 (positive regulation of mitochondrial depolarization)
GO:0055074 (calcium ion homeostasis)
GO:0060837 (blood vessel endothelial cell differentiation)
GO:0070371 (ERK1 and ERK2 cascade)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0090050 (positive regulation of cell migration involved in sprouting angiogenesis)
GO:0090141 (positive regulation of mitochondrial fission)
GO:0097755 (positive regulation of blood vessel diameter)
GO:1901532 (regulation of hematopoietic progenitor cell differentiation)
GO:1903010 (regulation of bone development)
GO:1904881 (cellular response to hydrogen sulfide)
GO:2000352 (negative regulation of endothelial cell apoptotic process)
GO:2001214 (positive regulation of vasculogenesis)

Target Cross References - Protein

canSAR P35918
IntAct P35918
Guide to Pharmacology 1813
MICAD NBK23448 (Vascular endothelial growth factor receptor 2 (VEGFR-2))
NBK23579 (Vascular endothelial growth factor receptor 2 (VEGFR-2))
NBK24606 (Vascular endothelial growth factor receptor 2 (VEGFR2))
NBK27085 (Vascular endothelial growth factor receptor-2 (VEGFR-2))
NBK52785 (Vascular endothelial growth factor receptor-2 (VEGFR-2))
NBK52786 (Vascular endothelial growth factor receptor-2 (VEGFR-2))
NBK52896 (Vascular endothelial growth factor receptor-2 (VEGFR-2))
NBK63872 (Vascular endothelial growth factor receptor 2 (VEGFR-2))
NBK82795 (Vascular endothelial growth factor receptor 2 (VEGFR-2))
UniProt C5H7S5 P35918

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001824 (Tyr_kinase_rcpt_3_CS.)
IPR003598 (Ig_sub2.)
IPR003599 (Ig_sub.)
IPR007110 (Ig-like_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR009136 (VEGFR2_rcpt.)
IPR011009 (Kinase-like_dom_sf.)
IPR013098 (Ig_I-set.)
IPR013783 (Ig-like_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR036179 (Ig-like_dom_sf.)
Pfam PF07679 (I-set)
PF07714 (Pkinase_Tyr)