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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3332
Target Type SINGLE PROTEIN
Preferred Name ADAM17
Synonyms ADAM 17 | ADAM17 | CD_antigen=CD156b | Disintegrin and metalloproteinase domain-containing protein 17 | TACE | TNF-alpha convertase | TNF-alpha-converting enzyme
Organism Sus scrofa
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m12b subfamily

Target Components

Component Description Relationship Accession
Disintegrin and metalloproteinase domain-containing protein 17 SINGLE PROTEIN O77636

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0016020 (membrane)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0005112 (Notch binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0006509 (membrane protein ectodomain proteolysis)
GO:0007219 (Notch signaling pathway)
GO:0007220 (Notch receptor processing)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)

Target Cross References - Protein

canSAR O77636
UniProt O77636

Target Cross References - Domain

InterPro IPR001590 (Peptidase_M12B.)
IPR024079 (MetalloPept_cat_dom.)
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